Oncological outcome and prognostic factors of surgery for soft tissue sarcoma after neoadjuvant or adjuvant radiation therapy: A retrospective analysis over 15 years
Muehlhofer HML, Schlossmacher B, Lenze U, Lenze F, Burgkart R, Gersing AS, Peeken JC, Combs SE, Von Eisenhart-Rothe R, Knebel C (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 41
Pages Range: 359-368
Journal Issue: 1
DOI: 10.21873/anticanres.14784
Abstract
Background/Aim: Surgical resection for soft tissue sarcomas (STSs) is the gold standard for a curative oncologic therapy in combination with neoadjuvant or adjuvant radiation therapy (NRT/ART). The aim of this study was to determine prognostic factors influencing the survival of patients with STS undergoing NRT or ART considering various parameters in a retrospective, single-centre analysis over 15 years. Patients and Methods: We included 119 patients (male 59) and the median follow-up period was 69 months (4-197). The patients received NRT (n=64) or ART (n=55). We recorded the histopathologic subtype of STS, tumour grade, localization, tumour margins, complications, survival, local recurrence, and metastases. Survival analysis was performed using the Kaplan-Meier method. Results: The overall survival rate was 68.9% at 5 years. The localization (epifascial/subfascial), resection margin and type of radiation therapy (NRT/ART) had no significant impact on survival. Tumour grade, tumour size, local recurrence and metastases were significantly correlated with patient survival (p<0.05). Local recurrence was significantly higher in patients with ART (p=0.044). Conclusion: Tumour grade and tumour size were independently associated with diseasespecific survival, and patients with local recurrence and metastases had lower survival rates.
Involved external institutions
Germany (DE)How to cite
APA:
Muehlhofer, H.M.L., Schlossmacher, B., Lenze, U., Lenze, F., Burgkart, R., Gersing, A.S.,... Knebel, C. (2021). Oncological outcome and prognostic factors of surgery for soft tissue sarcoma after neoadjuvant or adjuvant radiation therapy: A retrospective analysis over 15 years. Anticancer Research, 41(1), 359-368. https://doi.org/10.21873/anticanres.14784
MLA:
Muehlhofer, Heinrich M. L., et al. "Oncological outcome and prognostic factors of surgery for soft tissue sarcoma after neoadjuvant or adjuvant radiation therapy: A retrospective analysis over 15 years." Anticancer Research 41.1 (2021): 359-368.
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