Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions

Seguchi M, Aytekin A, Lenz T, Nicol P, Klosterman GR, Beele A, Sabic E, Utsch L, Alyaqoob A, Gorpas D, Ntziachristos V, Jaffer FA, Rauschendorfer P, Joner M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

European Heart Journal - Cardiovascular Imaging Oxford University Press

Book Volume: 24

Pages Range: e1-e16

Journal Issue: 1

DOI: 10.1093/ehjci/jeac163

Abstract

Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morphological changes in plaque composition but also relevant molecular processes resulting in increased plaque vulnerability. While existing intravascular imaging modalities are able to resolve key morphological features during plaque progression, they lack capability to characterize the molecular profile of advanced atherosclerotic plaque. Because hybrid imaging modalities may provide incremental information related to plaque biology, they are expected to provide synergistic effects in detecting high risk patients and lesions. The aim of this article is to review existing literature on intravascular molecular imaging approaches, and to provide clinically oriented proposals of their application. In addition, we assembled an overview of future developments in this field geared towards detection of patients at risk for cardiovascular events.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Harvard University US United States (USA) (US)

How to cite

APA:

Seguchi, M., Aytekin, A., Lenz, T., Nicol, P., Klosterman, G.R., Beele, A.,... Joner, M. (2022). Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions. European Heart Journal - Cardiovascular Imaging, 24(1), e1-e16. https://doi.org/10.1093/ehjci/jeac163

MLA:

Seguchi, Masaru, et al. "Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions." European Heart Journal - Cardiovascular Imaging 24.1 (2022): e1-e16.

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