ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries

Kaufmann JO, Brangsch J, Kader A, Saatz J, Mangarova DB, Zacharias M, Kempf WE, Schwaar T, Ponader M, Adams LC, Moeckel J, Botnar RM, Taupitz M, Maegdefessel L, Traub H, Hamm B, Weller MG, Makowski MR (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Nature Communications Nature Publishing Group: Nature Communications

Book Volume: 13

Article Number: 2867

Journal Issue: 1

DOI: 10.1038/s41467-022-30464-8

Abstract

The incidence of abdominal aortic aneurysms (AAAs) has substantially increased during the last 20 years and their rupture remains the third most common cause of sudden death in the cardiovascular field after myocardial infarction and stroke. The only established clinical parameter to assess AAAs is based on the aneurysm size. Novel biomarkers are needed to improve the assessment of the risk of rupture. ADAMTS4 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 4) is a strongly upregulated proteoglycan cleaving enzyme in the unstable course of AAAs. In the screening of a one-bead-one-compound library against ADAMTS4, a low-molecular-weight cyclic peptide is discovered with favorable properties for in vivo molecular magnetic resonance imaging applications. After identification and characterization, it’s potential is evaluated in an AAA mouse model. The ADAMTS4-specific probe enables the in vivo imaging-based prediction of aneurysm expansion and rupture.

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE) Bundesanstalt für Materialforschung und -prüfung (BAM) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) King’s College London GB United Kingdom (GB)

How to cite

APA:

Kaufmann, J.O., Brangsch, J., Kader, A., Saatz, J., Mangarova, D.B., Zacharias, M.,... Makowski, M.R. (2022). ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-30464-8

MLA:

Kaufmann, Jan O., et al. "ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries." Nature Communications 13.1 (2022).

BibTeX: Download