Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04

Notohamiprodjo S, Nekolla SG, Robu S, Asiares AV, Kupatt C, Ibrahim T, Laugwitz KL, Makowski MR, Schwaiger M, Weber WA, Varasteh Z (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Journal of Nuclear Cardiology Springer Verlag (Germany)

Book Volume: 29

Pages Range: 2254-2261

Journal Issue: 5

DOI: 10.1007/s12350-021-02603-z

Abstract

Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat model with 68Ga-FAPI-04-PET. In the current extended clinical case, we sought to delineate cardiac uptake of 68Ga-FAPI-04 in a patient after MI with clinical indication for the evidence of fibroblast activation. Carcinoma patients without cardiac disease underwent 68Ga-FAPI-04-PET/CT as control. The patient with one-vessel disease underwent dynamic 68Ga-FAPI-04-cardiac-PET/CMR for 60 minutes. Correlation of cardiac 68Ga-FAPI-04 uptake with clinical findings, ECG, echocardiography, coronary-arteriography and enhanced cardiac-MRI with T1 MOLLI and ECV mapping were performed. No uptake was found in normal myocardium and in mature scar. A focal intense 68Ga-FAPI-04 uptake with continuous wash-out in the infarct territory of coronary occlusion correlating with T1 and ECV mapping was observed. The uptake of 68Ga-FAPI-04 extends beyond the actual infarcted area and overestimates the infarct size as confirmed by follow-up CMR.

Involved external institutions

Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Notohamiprodjo, S., Nekolla, S.G., Robu, S., Asiares, A.V., Kupatt, C., Ibrahim, T.,... Varasteh, Z. (2022). Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04. Journal of Nuclear Cardiology, 29(5), 2254-2261. https://doi.org/10.1007/s12350-021-02603-z

MLA:

Notohamiprodjo, Susan, et al. "Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04." Journal of Nuclear Cardiology 29.5 (2022): 2254-2261.

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