A High‐Protein and Low‐Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High‐Risk Individuals

Rohling M, Kempf K, Banzer W, Braumann KM, Fuehrer-Sakel D, Halle M, Mccarthy D, Martin S, Scholze J, Toplak H, Berg A, Predel HG (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Nutrients MDPI

Book Volume: 14

Article Number: 1443

Journal Issue: 7

DOI: 10.3390/nu14071443

Abstract

Low‐caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high‐protein, low‐glycemic but moderate‐caloric formula diet. This post‐hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk‐ (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high‐risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2–4 weeks: 2 meals/day; 5–26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p < 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high‐protein and low‐glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high‐risk individuals with overweight and obesity.

Involved external institutions

Verbund Katholischer Kliniken Düsseldorf gGmbH (VKKD) DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE) Universität Hamburg (UHH) DE Germany (DE) Universität Duisburg-Essen (UDE) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) London Metropolitan University GB United Kingdom (GB) Albert-Ludwigs-Universität Freiburg DE Germany (DE) Deutsche Sporthochschule Köln DE Germany (DE)

How to cite

APA:

Rohling, M., Kempf, K., Banzer, W., Braumann, K.M., Fuehrer-Sakel, D., Halle, M.,... Predel, H.-G. (2022). A High‐Protein and Low‐Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High‐Risk Individuals. Nutrients, 14(7). https://dx.doi.org/10.3390/nu14071443

MLA:

Rohling, Martin, et al. "A High‐Protein and Low‐Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High‐Risk Individuals." Nutrients 14.7 (2022).

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