High-Protein, Low-Glycaemic Meal Replacement Improves Physical Health-Related Quality of Life in High-Risk Persons for Metabolic Syndrome—A Subanalysis of the Randomised-Controlled ACOORH Trial

Kempf K, Roehling M, Banzer W, Braumann KM, Halle M, Schaller N, Mccarthy D, Predel HG, Schenkenberger I, Tan S, Toplak H, Martin S, Berg A (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Nutrients MDPI

Book Volume: 14

Article Number: 3161

Journal Issue: 15

DOI: 10.3390/nu14153161

Abstract

While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been shown to successfully reduce weight, would also improve HRQOL more effectively than a lifestyle intervention alone. In the international, multicenter, randomised-controlled ACOORH-trial (Almased-Concept-against- Overweight-and-Obesity-and-Related-Health-Risk), overweight or obese participants with elevated risk for metabolic syndrome (n = 463) were randomised into two groups. Both groups received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement for 6 months. HRQOL was estimated at baseline, after 3 and 12 months, using the SF-36 questionnaire, and all datasets providing HRQOL data (n = 263) were included in this predefined subanalysis. Stronger improvements in the physical component summary (PCS) were observed in the intervention compared to the control group, peaking after 3 months (estimated treatment difference 2.7 [1.2; 4.2]; p < 0.0001), but also in the long-term. Multiple regression analysis demonstrated that insulin levels and the achieved weight loss were associated with the mental component summary (MCS) after 12 months (p < 0.05). Thus, meal replacement-based lifestyle intervention is not only effective in weight reduction but, concomitantly, in enhancing HRQOL.

Involved external institutions

Verbund Katholischer Kliniken Düsseldorf gGmbH (VKKD) DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE) Universität Hamburg (UHH) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) London Metropolitan University GB United Kingdom (GB) Deutsche Sporthochschule Köln DE Germany (DE) Universität Duisburg-Essen (UDE) DE Germany (DE) Albert-Ludwigs-Universität Freiburg DE Germany (DE)

How to cite

APA:

Kempf, K., Roehling, M., Banzer, W., Braumann, K.M., Halle, M., Schaller, N.,... Berg, A. (2022). High-Protein, Low-Glycaemic Meal Replacement Improves Physical Health-Related Quality of Life in High-Risk Persons for Metabolic Syndrome—A Subanalysis of the Randomised-Controlled ACOORH Trial. Nutrients, 14(15). https://dx.doi.org/10.3390/nu14153161

MLA:

Kempf, Kerstin, et al. "High-Protein, Low-Glycaemic Meal Replacement Improves Physical Health-Related Quality of Life in High-Risk Persons for Metabolic Syndrome—A Subanalysis of the Randomised-Controlled ACOORH Trial." Nutrients 14.15 (2022).

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