Determinants of oxygen utilization in breast cancer: Similarities between heart failure with preserved ejection fraction
Haykowsky MJ, Kirkham AA, Li T, Pituskin E, Thompson RB, Paterson DI, Foulkes SJ, Halle M, Sarma S, Howden E, Nelson MD, La Gerche A (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
Book Volume: 74
Pages Range: 45-52
DOI: 10.1016/j.pcad.2022.10.005
Abstract
Reduced exercise tolerance and fatigue are hallmark features in both breast cancer (BC) and heart failure with preserved ejection fraction (HFpEF) and are associated with decreased physical function and quality of life. This brief review focuses on the mechanisms of exercise intolerance in women with BC across the survivorship continuum and highlights how these disturbances within the oxygen transport cascade are similar to that of HFpEF patients. Specifically, the role that impaired cardiac, peripheral vascular and skeletal muscle function play in limiting peak oxygen uptake are discussed. We propose that women with BC are at increased risk of developing HFpEF potentially due to the adverse effects of chemotherapy and concurrent adverse lifestyle behaviors on cardiovascular and skeletal muscle function.
Involved external institutions
University of Alberta
Canada (CA)
University of Toronto
Canada (CA)
University of Texas Southwestern Medical Center (UT Southwestern)
United States (USA) (US)
Baker Idi Heart And Diabetes Institute
Australia (AU)
University of Texas at Arlington (UTA)
United States (USA) (US)
Canada (CA)
University of Toronto
Canada (CA)
University of Texas Southwestern Medical Center (UT Southwestern)
United States (USA) (US)
Baker Idi Heart And Diabetes Institute
Australia (AU)
University of Texas at Arlington (UTA)
United States (USA) (US)
How to cite
APA:
Haykowsky, M.J., Kirkham, A.A., Li, T., Pituskin, E., Thompson, R.B., Paterson, D.I.,... La Gerche, A. (2022). Determinants of oxygen utilization in breast cancer: Similarities between heart failure with preserved ejection fraction. Progress in Cardiovascular Diseases, 74, 45-52. https://doi.org/10.1016/j.pcad.2022.10.005
MLA:
Haykowsky, Mark J., et al. "Determinants of oxygen utilization in breast cancer: Similarities between heart failure with preserved ejection fraction." Progress in Cardiovascular Diseases 74 (2022): 45-52.
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