sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
Nasirigerdeh R, Torkzadehmahani R, Matschinske J, Frisch T, List M, Spaeth J, Weiss S, Voelker U, Pitkaenen E, Heider D, Wenke NK, Kaissis G, Rueckert D, Kacprowski T, Baumbach J (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 23
Article Number: 32
Journal Issue: 1
DOI: 10.1186/s13059-021-02562-1
Abstract
Meta-analysis has been established as an effective approach to combining summary statistics of several genome-wide association studies (GWAS). However, the accuracy of meta-analysis can be attenuated in the presence of cross-study heterogeneity. We present sPLINK, a hybrid federated and user-friendly tool, which performs privacy-aware GWAS on distributed datasets while preserving the accuracy of the results. sPLINK is robust against heterogeneous distributions of data across cohorts while meta-analysis considerably loses accuracy in such scenarios. sPLINK achieves practical runtime and acceptable network usage for chi-square and linear/logistic regression tests. sPLINK is available at https://exbio.wzw.tum.de/splink.
Involved external institutions
Universität Hamburg (UHH)
Germany (DE)
Universitätsmedizin Greifswald / Universitätsklinikum Greifswald
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
University of Southern Denmark / Syddansk Universitet
Denmark (DK)
Helsingin yliopisto / University of Helsinki
Finland (FI)
Technische Universität Braunschweig
Germany (DE)
Philipps-Universität Marburg
Germany (DE)
Germany (DE)
Universitätsmedizin Greifswald / Universitätsklinikum Greifswald
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
University of Southern Denmark / Syddansk Universitet
Denmark (DK)
Helsingin yliopisto / University of Helsinki
Finland (FI)
Technische Universität Braunschweig
Germany (DE)
Philipps-Universität Marburg
Germany (DE)
How to cite
APA:
Nasirigerdeh, R., Torkzadehmahani, R., Matschinske, J., Frisch, T., List, M., Spaeth, J.,... Baumbach, J. (2022). sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies. Genome Biology, 23(1). https://doi.org/10.1186/s13059-021-02562-1
MLA:
Nasirigerdeh, Reza, et al. "sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies." Genome Biology 23.1 (2022).
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