Coughlan JJ, Raber L, Brugaletta S, Kufner S, Maeng M, Jensen LO, Ortega-Paz L, Bar S, Laugwitz KL, Madsen M, Heg D, Aytekin A, Windecker S, Olesen KKW, Sabate M, Kastrati A, Cassese S (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 147
Pages Range: 575-585
Journal Issue: 7
DOI: 10.1161/CIRCULATIONAHA.122.062049
Background: Although some studies have investigated sex-related outcomes up to 5 years after percutaneous coronary intervention (PCI), analyses at longer follow-up (ie, to 10 years) in large cohorts treated exclusively with drug-eluting stent (DES) platforms are lacking. Therefore, this study aimed to define whether sex-related differences in long-term outcomes after PCI persist both in the DES era and at longer-term follow-up. Methods: Individual data of patients treated with DES in 5 randomized controlled trials with 10-year follow-up were pooled. Patients were divided into 2 groups by sex. The analysis of individual participant data was performed using a 1-stage approach by entering a clustering effect by parent study in all univariable and multivariable models focusing on sex. The main outcomes of interest for this analysis included cardiovascular death, myocardial infarction, repeat revascularization, and definite stent thrombosis to 10 years after PCI. Survival was analyzed by the Kaplan-Meier method to estimate the time to first event, and differences between the 2 groups were tested with the log-rank test. Hazard ratios (HRs) and 95% CIs were calculated with a Cox proportional hazards model. Conventional multivariable analyses with adjustment for relevant variables were performed. Results: Among 9700 patients undergoing PCI with DES implantation included in the present analysis, 2296 were women and 7404 were men. Through to 10 years, cardiovascular death occurred in 407 of the 2296 female patients and 1012 of the 7404 male patients (adjusted HR [HR
APA:
Coughlan, J.J., Raber, L., Brugaletta, S., Kufner, S., Maeng, M., Jensen, L.O.,... Cassese, S. (2023). Sex Differences in 10-Year Outcomes after Percutaneous Coronary Intervention with Drug-Eluting Stents: Insights from the DECADE Cooperation. Circulation, 147(7), 575-585. https://dx.doi.org/10.1161/CIRCULATIONAHA.122.062049
MLA:
Coughlan, J. J., et al. "Sex Differences in 10-Year Outcomes after Percutaneous Coronary Intervention with Drug-Eluting Stents: Insights from the DECADE Cooperation." Circulation 147.7 (2023): 575-585.
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