23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients

Kopp C, Linz P, Dahlmann A, Hammon M, Jantsch J, Mueller DN, Schmieder R, Cavallaro AJ, Eckardt KU, Uder M, Luft FC, Titze J (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Hypertension American Heart Association

Book Volume: 61

Pages Range: 635-640

Journal Issue: 3

DOI: 10.1161/HYPERTENSIONAHA.111.00566

Abstract

High dietary salt intake is associated with hypertension; the prevalence of salt-sensitive hypertension increases with age. We hypothesized that tissue Na might accumulate in hypertensive patients and that aging might be accompanied by Na deposition in tissue. We implemented Na magnetic resonance imaging to measure Na content of soft tissues in vivo earlier, but had not studied essential hypertension. We report on a cohort of 56 healthy control men and women, and 57 men and women with essential hypertension. The ages ranged from 22 to 90 years. Na magnetic resonance imaging measurements were made at the level of the calf. We observed age-dependent increases in Na content in muscle in men, whereas muscle Na content did not change with age in women. We estimated water content with conventional MRI and found no age-related increases in muscle water in men, despite remarkable Na accumulation, indicating water-free Na storage in muscle. With increasing age, there was Na deposition in the skin in both women and men; however, skin Na content remained lower in women. Similarly, this sex difference was found in skin water content, which was lower in women than in men. In contrast to muscle, increasing Na content was paralleled with increasing skin water content. When controlled for age, we found that patients with refractory hypertension had increased tissue Na content, compared with normotensive controls. These observations suggest that Na magnetic resonance imaging could have utility in assessing the role of tissue Na storage for cardiovascular morbidity and mortality in longitudinal studies. © 2013 American Heart Association, Inc.

Authors with CRIS profile

Christoph Kopp Department of Medicine 4 – Nephrology and Hypertension Peter Linz Interdisziplinäres Zentrum für Klinische Forschung IZKF-Förderlinien Anke Dahlmann Medizinische Fakultät Matthias Hammon Institute of Radiology Roland Schmieder Professur für Innere Medizin (Nephrologie) Alexander Josef Cavallaro Institute of Radiology Kai-Uwe Eckardt Department of Medicine 4 – Nephrology and Hypertension Michael Uder Lehrstuhl für Diagnostische Radiologie Jens Titze Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Experimental and Clinical Research Center (ECRC) DE Germany (DE)

How to cite

APA:

Kopp, C., Linz, P., Dahlmann, A., Hammon, M., Jantsch, J., Mueller, D.N.,... Titze, J. (2013). 23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients. Hypertension, 61(3), 635-640. https://doi.org/10.1161/HYPERTENSIONAHA.111.00566

MLA:

Kopp, Christoph, et al. "23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients." Hypertension 61.3 (2013): 635-640.

BibTeX: Download