Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography

Nakazato R, Gransar H, Berman DS, Cheng VY, Lin FY, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Delago A, Hadamitzky M, Hausleiter J, Kaufmann P, Maffei E, Raff G, Shaw LJ, Villines TC, Dunning A, Cury RC, Feuchtner G, Kim YJ, Leipsic J, Min JK (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Book Volume: 7

Pages Range: 83-90

Journal Issue: 2

DOI: 10.1016/j.jcct.2013.01.008

Abstract

Background: The association between lipoprotein levels and coronary plaque composition is not well understood. Objective: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). Methods: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). Results: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. Conclusion: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition. © 2013 Society of Cardiovascular Computed Tomography.

Authors with CRIS profile

Involved external institutions

Cedars-Sinai Medical Center United States (USA) (US) Oklahoma Heart Institute United States (USA) (US) Cornell University United States (USA) (US) Wayne State University (WSU) United States (USA) (US) Harbor–UCLA Medical Center United States (USA) (US) Casa di Cura Giovanni XXIII Italy (IT) Tennessee Heart & Vascular United States (USA) (US) Yonsei University Health System (YUHS) Korea, Republic of (KR) Beaumont Health System United States (USA) (US) University of Ottawa Canada (CA) Capitol Cardiology Associates United States (USA) (US) Deutsches Herzzentrum München Germany (DE) Universitätsspital Zürich (USZ) Switzerland (CH) Emory University United States (USA) (US) Walter Reed Army Medical Center (WRAMC) United States (USA) (US) New York Presbyterian Hospital United States (USA) (US) Baptist Health South Florida United States (USA) (US) Medizinische Universität Innsbruck Austria (AT) Seoul National University (SNU) / 서울대학교 Korea, Republic of (KR) University of British Columbia Canada (CA)

How to cite

APA:

Nakazato, R., Gransar, H., Berman, D.S., Cheng, V.Y., Lin, F.Y., Achenbach, S.,... Min, J.K. (2013). Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography. Journal of Cardiovascular Computed Tomography, 7(2), 83-90. https://doi.org/10.1016/j.jcct.2013.01.008

MLA:

Nakazato, Ryo, et al. "Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography." Journal of Cardiovascular Computed Tomography 7.2 (2013): 83-90.

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