Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine

Heidbreder K, Sommer K, Wiendl M, Müller T, Atreya I, Hildner K, Neurath M, Zundler S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 13

Article Number: 1040775

DOI: 10.3389/fimmu.2022.1040775

Abstract

Introduction: Macrophages play an important role in intestinal wound healing. However, the trajectories from circulating monocytes to gut macrophages are incompletely understood. Methods: Taking advantage of mice depleted for non-classical monocytes due to deficiency for the transcription factor Nr4a1, we addressed the relevance of non-classical monocytes for large intestinal wound healing using flow cytometry, in vivo wound healing assays and immunofluorescence. Results: We show that wound healing in Nr4a1-deficient mice is substantially delayed and associated with reduced peri-lesional presence of macrophages with a wound healing phenotype. Discussion: Our data suggest that non-classical monocytes are biased towards wound healing macrophages. These insights might help to understand, how targeting monocyte recruitment to the intestine can be used to modulate intestinal macrophage functions.

Authors with CRIS profile

Katrin Sommer Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Maximilian Wiendl Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Tanja Müller Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Imke Atreya Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Kai Hildner Juniorprofessur für Pneumologie/ Immunologie Markus Neurath Lehrstuhl für Innere Medizin I Sebastian Zundler Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

How to cite

APA:

Heidbreder, K., Sommer, K., Wiendl, M., Müller, T., Atreya, I., Hildner, K.,... Zundler, S. (2023). Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1040775

MLA:

Heidbreder, Karin, et al. "Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine." Frontiers in Immunology 13 (2023).

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