Salvage total glossectomy and total glosso-laryngectomy: Are they worth it? A GETTEC French multicenter study.
Mazerolle P, Fuchsmann C, Schultz P, Benmoussa N, Malard O, Bozec A, Deneuve S, Folia M, Perreard M, Lasne-Cardon A, Chabrillac E, Vergez S, Chaltiel L, Dupret-Bories A (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 130
DOI: 10.1016/j.oraloncology.2022.105896
Abstract
BACKGROUND: Salvage total glossectomy (TG) or total glosso-laryngectomy (TGL) remain controversial, as highly morbid procedures. The objective was to describe oncological and functional outcomes after salvage TG or TGL. METHODS: We performed a multicenter retrospective study, including patients with previous neck irradiation undergoing TG or TGL for squamous cell carcinoma involving the base of tongue. RESULTS: We included 42 patients: 27 in the TG group and 15 in the TGL group. For the entire cohort, median OS and DFS were estimated at 19 months (95% IC [14-44]) and 10 months (95% IC [7-13]) respectively, with no difference between the two groups. After a median follow-up of 90 months, 10 patients (24%) were alive and free of disease. Att he end of follow-up, we noted a gastrostomy dependency of 89% and 87 %respectively in the TG and TGL group, and 48% of patients in the TG group had a tracheotomy. CONCLUSION: Although local control is difficult to achieve after salvage TG or TGL, these procedures are associated with acceptable survival and chance of cure for a last-resort situation. TG and TGL can be proposed in selected motivated patients after careful shared decision-making.
Involved external institutions
Centre Hospitalier Universitaire (CHU) de Toulouse
France (FR)
Hospices Civils de Lyon (CHU)
France (FR)
Hôpital de Hautepierre
France (FR)
École Polytechnique - Université Paris-Saclay
France (FR)
Nantes University Hospital / Centre hospitalier universitaire de Nantes (CHU)
France (FR)
University Institute of the Face and Neck / Institut universitaire de la face et du cou
France (FR)
Centre Léon-Bérard (UNICANCER)
France (FR)
Straub Medical AG
Switzerland (CH)
Centre Hospitalier Universitaire de Caen
France (FR)
Center François Baclesse
France (FR)
Toulouse Oncopole Cancer University Institute (IUCT-O) / Institut universitaire du cancer de Toulouse Oncopole (IUCT-O)
France (FR)
France (FR)
Hospices Civils de Lyon (CHU)
France (FR)
Hôpital de Hautepierre
France (FR)
École Polytechnique - Université Paris-Saclay
France (FR)
Nantes University Hospital / Centre hospitalier universitaire de Nantes (CHU)
France (FR)
University Institute of the Face and Neck / Institut universitaire de la face et du cou
France (FR)
Centre Léon-Bérard (UNICANCER)
France (FR)
Straub Medical AG
Switzerland (CH)
Centre Hospitalier Universitaire de Caen
France (FR)
Center François Baclesse
France (FR)
Toulouse Oncopole Cancer University Institute (IUCT-O) / Institut universitaire du cancer de Toulouse Oncopole (IUCT-O)
France (FR)
How to cite
APA:
Mazerolle, P., Fuchsmann, C., Schultz, P., Benmoussa, N., Malard, O., Bozec, A.,... Dupret-Bories, A. (2022). Salvage total glossectomy and total glosso-laryngectomy: Are they worth it? A GETTEC French multicenter study. Oral Oncology, 130. https://dx.doi.org/10.1016/j.oraloncology.2022.105896
MLA:
Mazerolle, Paul, et al. "Salvage total glossectomy and total glosso-laryngectomy: Are they worth it? A GETTEC French multicenter study." Oral Oncology 130 (2022).
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