Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis

Hawerkamp HC, Caoimhe F, Fallon PG, Schwartz C (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Skin Health and Disease Wiley

Book Volume: 2

Issue: 2

DOI: 10.1002/ski2.99

Abstract

The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances made in the field of the skin innate immune system and its interaction with adaptive immunity. We review gene variants associated with atopic dermatitis and psoriasis that affect innate immune mechanisms and skin barrier integrity. Finally, we discuss how current and future therapies may affect innate immune responses and skin barrier integrity in a generalized or more targeted approach in order to ameliorate disease in patients.

Authors with CRIS profile

Christian Schwartz Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung (IZKF)

Related research project(s)

J079: Functional impact of PD-L1:PD-1-interactions on diet-induced obesity and dysbiosis Sept. 1, 2019 - Aug. 31, 2022

Involved external institutions

Trinity College Dublin IE Ireland (IE) Temple Street Children's University Hospital / Children's Health Ireland (CHI) IE Ireland (IE)

How to cite

APA:

Hawerkamp, H.C., Caoimhe, F., Fallon, P.G., & Schwartz, C. (2022). Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis. Skin Health and Disease, 2. https://doi.org/10.1002/ski2.99

MLA:

Hawerkamp, Heike C., et al. "Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis." Skin Health and Disease 2 (2022).

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