von Wilmowsky C, Lutz R, Meisel U, Srour S, Rupprecht S, Toyoshima T, Nkenke E, Schlegel KA, Pohle D, Münstedt H, Rechtenwald T, Schmidt M (2009)
Publication Type: Journal article
Publication year: 2009
Book Volume: 24
Pages Range: 169-184
Journal Issue: 2
The aim of this study was to produce an individually shaped medical implant from a 3D database and to evaluate the biological behavior of a laser sintered poly(ether ether ketone) (PEEK) implant with incorporated osteoconductive bone materials in porcine bone defects. Laser sintered PEEK samples containing ß-tricalciumphosphate (ß-TCP) were implanted into critical size defects in the frontal skull of ten pigs. Compression moulded pure PEEK was used as a reference material. The bone-implant interface was histomorphometrically analysed after 6, 12, and 24 weeks. Histomorphometrical evaluations after 24 weeks revealed that the superficially located ß-TCP was in contact with the surrounding bone, whereas the other groups were fibrous encapsulated. Interfacial shear strength was significantly higher for the ß-TCP containing group in comparison to the compression moulded PEEK group (p = 0.004) and the laser sintered PEEK group. The laser sintered PEEK implants seem to be attractive as bone substitutes for reconstructive surgery due to their individually constructed 3D shape and biocompatibility. © 2009 SAGE Publications.
APA:
von Wilmowsky, C., Lutz, R., Meisel, U., Srour, S., Rupprecht, S., Toyoshima, T.,... Schmidt, M. (2009). In vivo evaluation of B-TCP containing 3D laser sintered poly(ether ether ketone) composites in pigs. Journal of Bioactive and Compatible Polymers, 24(2), 169-184. https://doi.org/10.1177/0883911508101149
MLA:
von Wilmowsky, Cornelius, et al. "In vivo evaluation of B-TCP containing 3D laser sintered poly(ether ether ketone) composites in pigs." Journal of Bioactive and Compatible Polymers 24.2 (2009): 169-184.
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