Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders: An Observational Multicenter Study in France.

Hoertel N, Sanchez-Rico M, de la Muela P, Abellán M, Blanco C, Leboyer M, Cougoule C, Gulbins E, Kornhuber J, Carpinteiro A, Becker KA, Vernet R, Beeker N, Neuraz A, Alvarado JM, Jose Herrera-Morueco J, Airagnes G, Lemogne C, Limosin F (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Biological Psychiatry Global Open Science Elsevier

Book Volume: 3

Pages Range: 56-67

Journal Issue: 1

DOI: 10.1016/j.bpsgos.2021.12.007

Abstract

BACKGROUND: Prior research suggests that psychiatric disorders could be linked to increased mortality among patients with COVID-19. However, whether all or specific psychiatric disorders are intrinsic risk factors of death in COVID-19 or whether these associations reflect the greater prevalence of medical risk factors in people with psychiatric disorders has yet to be evaluated. METHODS: We performed an observational, multicenter, retrospective cohort study to examine the association between psychiatric disorders and mortality among patients hospitalized for laboratory-confirmed COVID-19 at 36 Greater Paris University hospitals. RESULTS: Of 15,168 adult patients, 857 (5.7%) had an ICD-10 diagnosis of psychiatric disorder. Over a mean follow-up period of 14.6 days (SD = 17.9), 326 of 857 (38.0%) patients with a diagnosis of psychiatric disorder died compared with 1276 of 14,311 (8.9%) patients without such a diagnosis (odds ratio 6.27, 95% CI 5.40-7.28, p < .01). When adjusting for age, sex, hospital, current smoking status, and medications according to compassionate use or as part of a clinical trial, this association remained significant (adjusted odds ratio 3.27, 95% CI 2.78-3.85, p < .01). However, additional adjustments for obesity and number of medical conditions resulted in a nonsignificant association (adjusted odds ratio 1.02, 95% CI 0.84-1.23, p = .86). Exploratory analyses after the same adjustments suggested that a diagnosis of mood disorders was significantly associated with reduced mortality, which might be explained by the use of antidepressants. CONCLUSIONS: These findings suggest that the increased risk of COVID-19-related mortality in individuals with psychiatric disorders hospitalized for COVID-19 might be explained by the greater number of medical conditions and the higher prevalence of obesity in this population and not by the underlying psychiatric disease.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

Université de Paris FR France (FR) Universidad Complutense de Madrid (UCM) ES Spain (ES) Université Sorbonne Paris Cité FR France (FR) National Institute on Drug Abuse (NIDA) US United States (USA) (US) Assistance Publique-Hôpitaux de Paris (AP-HP) FR France (FR) Universität Duisburg-Essen (UDE) DE Germany (DE) Hôpital Corentin-Celton, Hospital Corentin-Celton, APHP FR France (FR) Université Fédérale de Toulouse Midi-Pyrénées FR France (FR) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) FR France (FR) Universitätsklinikum Essen DE Germany (DE)

How to cite

APA:

Hoertel, N., Sanchez-Rico, M., de la Muela, P., Abellán, M., Blanco, C., Leboyer, M.,... Limosin, F. (2023). Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders: An Observational Multicenter Study in France. Biological Psychiatry Global Open Science, 3(1), 56-67. https://dx.doi.org/10.1016/j.bpsgos.2021.12.007

MLA:

Hoertel, Nicolas, et al. "Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders: An Observational Multicenter Study in France." Biological Psychiatry Global Open Science 3.1 (2023): 56-67.

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