Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity

Hild B, Dreier MS, Oh JH, Mcculloch JA, Badger JH, Guo J, Thefaine CE, Umarova R, Hall KD, Gavrilova O, Rosshart SP, Trinchieri G, Rehermann B (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Nature Metabolism Nature Research

Book Volume: 3

Pages Range: 1042-1057

Journal Issue: 8

DOI: 10.1038/s42255-021-00439-y

Abstract

Obesity and its consequences are among the greatest challenges in healthcare. The gut microbiome is recognized as a key factor in the pathogenesis of obesity. Using a mouse model, we show here that a wild-derived microbiome protects against excessive weight gain, severe fatty liver disease and metabolic syndrome during a 10-week course of high-fat diet. This phenotype is transferable only during the first weeks of life. In adult mice, neither transfer nor severe disturbance of the wild-type microbiome modifies the metabolic response to a high-fat diet. The protective phenotype is associated with increased secretion of metabolic hormones and increased energy expenditure through activation of brown adipose tissue. Thus, we identify a microbiome that protects against weight gain and its negative consequences through metabolic programming in early life. Translation of these results to humans may identify early-life therapeutics that protect against obesity.

Authors with CRIS profile

Stephan Patrick Rosshart

Involved external institutions

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK / NIDDKD) US United States (USA) (US) National Cancer Institute (NCI) US United States (USA) (US)

How to cite

APA:

Hild, B., Dreier, M.S., Oh, J.H., Mcculloch, J.A., Badger, J.H., Guo, J.,... Rehermann, B. (2021). Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity. Nature Metabolism, 3(8), 1042-1057. https://dx.doi.org/10.1038/s42255-021-00439-y

MLA:

Hild, Benedikt, et al. "Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity." Nature Metabolism 3.8 (2021): 1042-1057.

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