Evidence-based vertigo therapy;Meta-analysis of randomized primary pharmacotherapy trials Evidenzbasierte Schwindeltherapie: Metaanalyse randomisierter Primärstudien zur Pharmakotherapie
Waldfahrer F, Scholtz AW (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 41
Pages Range: 783-788
Journal Issue: 11
DOI: 10.1055/a-1910-9858
Abstract
The aim of the present meta-analysis was to evaluate the efficacy and safety of the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg in comparison with various other antivertigo treatments in patients with central and/or peripheral vestibular vertigo. For this purpose, individual patient data from 4 randomised, double-blind, controlled clinical trials with almost identical study design were pooled. In total, the data of 795 patients with vertigo of different origin (central and/or peripheral-vestibular) were included in the analysis. In all 4 included studies, patients were treated for 4 weeks with the test medication (fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg), with different comparators (cinnarizine 20 mg, 50 mg, dimenhydrinate 40 mg, 100 mg, betahistine dimesylate 12 mg, betahistine dihydrochloride 16 mg) or a placebo. The main outcome of the meta-analysis was the change in vertigo symptoms after 4 weeks of treatment. Patients' subjective vertigo symptoms were assessed using a validated vertigo score (Mean Vertigo Score, MVS). Secondary outcome measures included various response rates, change in concomitant vegetative symptoms and investigator and patient ratings of efficacy and tolerability. In summary, the results of the present meta-analysis suggest that the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg is a potentially superior treatment option for central and/or peripheral vertigo, with significantly better efficacy compared to other antivertigo treatments while being well tolerated.
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APA:
Waldfahrer, F., & Scholtz, A.W. (2022). Evidence-based vertigo therapy;Meta-analysis of randomized primary pharmacotherapy trials Evidenzbasierte Schwindeltherapie: Metaanalyse randomisierter Primärstudien zur Pharmakotherapie. Nervenheilkunde, 41(11), 783-788. https://dx.doi.org/10.1055/a-1910-9858
MLA:
Waldfahrer, Frank, and Arne W. Scholtz. "Evidence-based vertigo therapy;Meta-analysis of randomized primary pharmacotherapy trials Evidenzbasierte Schwindeltherapie: Metaanalyse randomisierter Primärstudien zur Pharmakotherapie." Nervenheilkunde 41.11 (2022): 783-788.
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