Chitin induces upregulation of B7-H1 on macrophages and inhibits T-cell proliferation
Wagner C, Huber S, Wirth S, Voehringer D (2010)
Publication Type: Journal article
Publication year: 2010
Journal
Book Volume: 40
Pages Range: 2882-2890
Journal Issue: 10
Abstract
Chitin is a highly abundant glycopolymer, which serves as structural component in fungi, arthropods and crustaceans but is not synthesized by vertebrates. However, vertebrates express chitinases and chitinase-like proteins, some of which are induced by infection with helminths suggesting that chitinous structures may be targets of the immune system. The chitin-induced modulations of the innate and adaptive immune responses are not well understood. Here, we demonstrate that intranasal administration of OVA and chitin resulted in diminished T-cell expansion and Th2 polarization as compared with OVA administration alone. Chitin did not promote nor attenuate Th2 polarization in vitro. Chitin-exposed macrophages inhibited proliferation of CD4+ T cells in a cell-cell contact-dependent manner. Chitin induced upregulation of the inhibitory ligand B7-H1 (PD-L1) on macrophages independently of MyD88, TRIF, TLR2, TLR3, TLR4 and Stat6. Inhibition of T-cell proliferation was largely dependent on B7-H1, as the effect was not observed in cocultures with cells from B7-H1-deficient mice. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
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Germany (DE)How to cite
APA:
Wagner, C., Huber, S., Wirth, S., & Voehringer, D. (2010). Chitin induces upregulation of B7-H1 on macrophages and inhibits T-cell proliferation. European Journal of Immunology, 40(10), 2882-2890. https://dx.doi.org/10.1002/eji.201040422
MLA:
Wagner, Claudia, et al. "Chitin induces upregulation of B7-H1 on macrophages and inhibits T-cell proliferation." European Journal of Immunology 40.10 (2010): 2882-2890.
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