Electrophysiological and neurochemical techniques to investigate sensory neurons in analgesia research.

Babes A, Fischer MJM, Reid G, Sauer S, Zimmermann K, Reeh P (2010)

Publication Type: Journal article

Publication year: 2010

Journal

Methods in Molecular Biology Humana Press

Book Volume: 617

Pages Range: 237-259

DOI: 10.1007/978-1-60327-323-7_19

Abstract

The primary afferent nociceptive neuron has recently attracted major research interest because of the cloning of very selectively expressed and well-conserved ion channel genes. All parts of the neuron, sensory terminals, axon and cell body, are accessible to validated research techniques in vitro using various isolated tissues or cells taken from laboratory animals. Single-unit recording and measuring stimulated calcitonin gene-related peptide (CGRP) release as well as patch-clamping and calcium imaging of cultured sensory neurons provide different kinds of information, and no model alone answers all questions. In combination, however, consistent results and complementary evidence form a solid basis for translational research to follow.

Authors with CRIS profile

Susanne Sauer Lehrstuhl für Physiologie Peter Reeh Professur für Physiologie

Involved external institutions

University of Bucharest / Universitatea din București RO Romania (RO) University College Cork (UCC) IE Ireland (IE)

How to cite

APA:

Babes, A., Fischer, M.J.M., Reid, G., Sauer, S., Zimmermann, K., & Reeh, P. (2010). Electrophysiological and neurochemical techniques to investigate sensory neurons in analgesia research. Methods in Molecular Biology, 617, 237-259. https://dx.doi.org/10.1007/978-1-60327-323-7_19

MLA:

Babes, Alexandru, et al. "Electrophysiological and neurochemical techniques to investigate sensory neurons in analgesia research." Methods in Molecular Biology 617 (2010): 237-259.

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