Neutrophils’ Extracellular Trap Mechanisms: From Physiology to Pathology

Schoen J, Euler M, Schauer C, Schett G, Herrmann M, Knopf J, Yaykasli KO (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 23

Article Number: 12855

Journal Issue: 21

DOI: 10.3390/ijms232112855

Abstract

Neutrophils are an essential part of the innate immune system and the first line of defense against invading pathogens. They phagocytose, release granular contents, produce reactive oxygen species, and form neutrophil extracellular traps (NETs) to fight pathogens. With the characterization of NETs and their components, neutrophils were identified as players of the innate adaptive crosstalk. This has placed NETs at the center not only of physiological but also pathological processes. Aside from their role in pathogen uptake and clearance, NETs have been demonstrated to contribute to the resolution of inflammation by forming aggregated NETs able to degrade inflammatory mediators. On the other hand, NETs have the potential to foster severe pathological conditions. When homeostasis is disrupted, they occlude vessels and ducts, serve as sources of autoantigens and danger or damage associated molecular patterns, directly damage tissues, and exaggerate complement activity and inflammation. This review focusses on the understanding of NETs from their formation to their functions in both physiological and pathological processes.

Authors with CRIS profile

Janina Schoen Department of Medicine 3 – Rheumatology and Immunology Maximilien Euler Department of Medicine 3 – Rheumatology and Immunology Christine Schauer Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology Jasmin Knopf Department of Medicine 3 – Rheumatology and Immunology Kürsat Oguz Yaykasli Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Schoen, J., Euler, M., Schauer, C., Schett, G., Herrmann, M., Knopf, J., & Yaykasli, K.O. (2022). Neutrophils’ Extracellular Trap Mechanisms: From Physiology to Pathology. International Journal of Molecular Sciences, 23(21). https://doi.org/10.3390/ijms232112855

MLA:

Schoen, Janina, et al. "Neutrophils’ Extracellular Trap Mechanisms: From Physiology to Pathology." International Journal of Molecular Sciences 23.21 (2022).

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