Multispectral optoacoustic tomography for the non-invasive identification of patients with severe anemia in vivo

Ganzleben I, Klett D, Hartz W, Götzfried L, Vitali F, Neurath M, Waldner M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Photoacoustics Elsevier

Book Volume: 28

Article Number: 100414

DOI: 10.1016/j.pacs.2022.100414

Abstract

The immediate diagnosis of severe anemia is crucial for patient outcome. However, reliable non-invasive point-of-care diagnostic tools for e.g., ICU monitoring are currently lacking. Using an advanced Multispectral Optoacoustic Tomography (MSOT) research device, we first substantiated a strong positive correlation of MSOT-signal and absolute hemoglobin concentration ex vivo in blood samples. In a clinical exploratory proof-of-concept study, we then evaluated 19 patients with different severities of anemia and controls by non-invasive in vivo measurement of hemoglobin in the radial artery. Our approach proved excellent in identifying patients with severe anemia triggering RBC transfusion based on a strong positive correlation of MSOT-signal intensity and hemoglobin concentration for 700 nm single wavelength and HbR unmixed MSOT-parameter analysis. In conclusion, our study lays the foundation to further develop MSOT-based real-time quantitative perfusion analyses in follow-up preclinical and clinical imaging studies and as a promising diagnostic tool to improve patient care in the future. DRKS00021442

Authors with CRIS profile

Ingo Ganzleben Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Daniel Klett Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Wiebke Hartz Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Francesco Vitali Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Markus Neurath Lehrstuhl für Innere Medizin I Maximilian Waldner Lehrstuhl für Innere Medizin I

How to cite

APA:

Ganzleben, I., Klett, D., Hartz, W., Götzfried, L., Vitali, F., Neurath, M., & Waldner, M. (2022). Multispectral optoacoustic tomography for the non-invasive identification of patients with severe anemia in vivo. Photoacoustics, 28. https://doi.org/10.1016/j.pacs.2022.100414

MLA:

Ganzleben, Ingo, et al. "Multispectral optoacoustic tomography for the non-invasive identification of patients with severe anemia in vivo." Photoacoustics 28 (2022).

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