Open-source image analysis tool for the identification and quantification of cortical interruptions and bone erosions in high-resolution peripheral quantitative computed tomography images of patients with rheumatoid arthritis
Zhao M, Tse JJ, Kuczynski MT, Brunet SC, Yan R, Engelke K, Peters M, van den Bergh JP, van Rietbergen B, Stok KS, Barnabe C, Pauchard Y, Manske SL (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 165
Article Number: 116571
DOI: 10.1016/j.bone.2022.116571
Abstract
Identification of bone erosions and quantification of erosion volume is important for rheumatoid arthritis diagnosis, and can add important information to evaluate disease progression and treatment effects. High-resolution peripheral quantitative computed tomography (HR-pQCT) is well suited for this purpose, however analysis methods are not widely available. The purpose of this study was to develop an open-source software tool for the identification and quantification of bone erosions using images acquired by HR-pQCT. The collection of modules, Bone Analysis Modules (BAM) – Erosion, implements previously published erosion analysis techniques as modules in 3D Slicer, an open-source image processing and visualization tool. BAM includes a module to automatically identify cortical interruptions, from which erosions are manually selected, and a hybrid module that combines morphological and level set operations to quantify the volume of bone erosions. HR-pQCT images of the second and third metacarpophalangeal (MCP) joints were acquired in patients with RA (XtremeCT, n = 14, XtremeCTII, n = 22). The number of cortical interruptions detected by BAM-Erosion agreed strongly with the previously published cortical interruption detection algorithm for both XtremeCT (r2 = 0.85) and XtremeCTII (r2 = 0.87). Erosion volume assessment by BAM-Erosion agreed strongly (r2 = 0.95) with the Medical Image Analysis Framework. BAM-Erosion provides an open-source erosion analysis tool that produces comparable results to previously published algorithms, with improved options for visualization. The strength of the tool is that it implements multiple image processing algorithms for erosion analysis on a single, widely available, open-source platform that can accommodate future updates.
Authors with CRIS profile
Involved external institutions
University of Calgary
Canada (CA)
Maastricht University
Netherlands (NL)
Eindhoven University of Technology / Technische Universiteit Eindhoven (TU/e)
Netherlands (NL)
The University of Melbourne
Australia (AU)
McCaig Institute for Bone and Joint Health
Canada (CA)
Canada (CA)
Maastricht University
Netherlands (NL)
Eindhoven University of Technology / Technische Universiteit Eindhoven (TU/e)
Netherlands (NL)
The University of Melbourne
Australia (AU)
McCaig Institute for Bone and Joint Health
Canada (CA)
How to cite
APA:
Zhao, M., Tse, J.J., Kuczynski, M.T., Brunet, S.C., Yan, R., Engelke, K.,... Manske, S.L. (2022). Open-source image analysis tool for the identification and quantification of cortical interruptions and bone erosions in high-resolution peripheral quantitative computed tomography images of patients with rheumatoid arthritis. Bone, 165. https://doi.org/10.1016/j.bone.2022.116571
MLA:
Zhao, Mingjie, et al. "Open-source image analysis tool for the identification and quantification of cortical interruptions and bone erosions in high-resolution peripheral quantitative computed tomography images of patients with rheumatoid arthritis." Bone 165 (2022).
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