Response to Oswald et al.: ST6Gal1 in plasma is dispensable for IgG sialylation

Werner A, Nimmerjahn F (2022)


Publication Type: Journal article, Letter

Publication year: 2022

Journal

DOI: 10.1093/glycob/cwac055

Abstract

The presence or absence of terminal sialic acid residues in the sugar moiety attached to the Fc-domain of IgG molecules modulates IgG activity and is associated with autoimmune or infection related inflammation. In a recent paper, Oswald and colleagues suggest that IgG sialylation may occur post IgG secretion from plasma cells, which would be a major issue for therapeutic antibodies injected into patients. In contrast, we argue that previous work rather demonstrates that IgG sialylation occurs within B cells and that the experimental system used by the authors is not suitable to address this critical question.

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How to cite

APA:

Werner, A., & Nimmerjahn, F. (2022). Response to Oswald et al.: ST6Gal1 in plasma is dispensable for IgG sialylation. Glycobiology. https://doi.org/10.1093/glycob/cwac055

MLA:

Werner, Anja, and Falk Nimmerjahn. "Response to Oswald et al.: ST6Gal1 in plasma is dispensable for IgG sialylation." Glycobiology (2022).

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