Amyloid-beta levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy

Oberstein T, Schmidt M, Florvaag A, Haas AL, Siegmann EM, Olm P, Utz J, Spitzer P, Dörfler A, Lewczuk P, Kornhuber J, Maler JM (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Brain Oxford University Press

DOI: 10.1093/brain/awac297

Abstract

In a long-term observational study, Oberstein et al. find that the biomarker constellation of increased pTau181, A beta 40 and A beta 42 in CSF is not associated with dementia. Further investigation of this biomarker profile may provide insights into the circumstances under which A beta becomes pathological.

Authors with CRIS profile

Timo Oberstein Department of Psychiatry and Psychotherapy Manuel Schmidt Neuroradiologisches Institut Anna-Lena Haas Medizinische Fakultät Eva-Maria Siegmann Department of Psychiatry and Psychotherapy Janine Utz Department of Psychiatry and Psychotherapy Philipp Spitzer Department of Psychiatry and Psychotherapy Arnd Dörfler
Piotr Lewczuk Department of Psychiatry and Psychotherapy Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Juan Manuel Maler Department of Psychiatry and Psychotherapy

Involved external institutions

Klinikum Nürnberg DE Germany (DE)

How to cite

APA:

Oberstein, T., Schmidt, M., Florvaag, A., Haas, A.-L., Siegmann, E.-M., Olm, P.,... Maler, J.M. (2022). Amyloid-beta levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy. Brain. https://doi.org/10.1093/brain/awac297

MLA:

Oberstein, Timo, et al. "Amyloid-beta levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy." Brain (2022).

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