The role of adult hippocampal neurogenesis in brain health and disease
Toda T, Parylak SL, Linker SB, Gage FH (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 24
Pages Range: 67-87
Journal Issue: 1
DOI: 10.1038/s41380-018-0036-2
Abstract
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.
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APA:
Toda, T., Parylak, S.L., Linker, S.B., & Gage, F.H. (2019). The role of adult hippocampal neurogenesis in brain health and disease. Molecular Psychiatry, 24(1), 67-87. https://doi.org/10.1038/s41380-018-0036-2
MLA:
Toda, Tomohisa, et al. "The role of adult hippocampal neurogenesis in brain health and disease." Molecular Psychiatry 24.1 (2019): 67-87.
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