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Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour

Georgiesh T, Aggerholm-Pedersen N, Schoffski P, Zhang Y, Napolitano A, Bovee JVMG, Hjelle A, Tang G, Spalek M, Nannini M, Swanson D, Baad-Hansen T, Sciot R, Hesla AC, Huang P, Dorleijn D, Haugland HK, Lacambra M, Skoczylas J, Pantaleo MA, Haas RL, Meza-Zepeda LA, Haller F, Czarnecka AM, Loong H, Jebsen NL, Van De Sande M, Jones RL, Haglund F, Timmermans I, Safwat A, Bjerkehagen B, Boye K (2022)

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Publication Type: Journal article

Publication year: 2022

Journal

DOI: 10.1038/s41416-022-01959-4

Abstract

Background Current risk models in solitary fibrous tumour (SFT) were developed using cohorts with short follow-up and cannot reliably identify low-risk patients. We recently developed a novel risk model (G-score) to account for both early and late recurrences. Here, we aimed to validate the G-score in a large international cohort with long-term follow-up. Methods Data were collected from nine sarcoma referral centres worldwide. Recurrence-free interval (RFi) was the primary endpoint. Results The cohort comprised 318 patients with localised extrameningeal SFTs. Disease recurrence occurred in 96 patients (33%). The estimated 5-year RFi rate was 72%, and the 10-year RFi rate was 52%. G-score precisely predicted recurrence risk with estimated 10-year RFi rate of 84% in low risk, 54% in intermediate risk and 36% in high risk (p < 0.001; C-index 0.691). The mDemicco (p < 0.001; C-index 0.749) and Salas(OS) (p < 0.001; C-index 0.674) models also predicted RFi but identified low-risk patients less accurate with 10-year RFi rates of 72% and 70%, respectively. Conclusions G-score is a highly significant predictor of early and late recurrence in SFT and is superior to other models to predict patients at low risk of relapse. A less intensive follow-up schedule could be considered for patients at low recurrence risk according to G-score.

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How to cite

APA:

Georgiesh, T., Aggerholm-Pedersen, N., Schoffski, P., Zhang, Y., Napolitano, A., Bovee, J.V.M.G.,... Boye, K. (2022). Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour. British Journal of Cancer. https://dx.doi.org/10.1038/s41416-022-01959-4

MLA:

Georgiesh, Tatiana, et al. "Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour." British Journal of Cancer (2022).

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