Process concepts

Kaspereit M, Schmidt-Traub H (2020)

Publication Language: English

Publication Type: Book chapter / Article in edited volumes

Publication year: 2020

Publisher: John Wiley & Sons, Ltd.

Edited Volumes: Preparative Chromatography: Third Edition

ISBN: 9783527816316

DOI: 10.1002/9783527816347.ch5


A variety of operating modes and process configurations exist for designing efficient chromatographic separations. Decisions to bemade concern a pulse-wise or continuous feed introduction, operation in a single- or multi-column mode, elution under isocratic or gradient conditions, co-, cross-, or counter-current flow of mobile and stationary phases, and withdrawal of two or a multitude of fractions. Furthermore, while fine chemicals are of low molecular weight, biomolecules have a molecular weight up to several million and may undergo a denaturation. Correspondingly, the type of the molecules to be separated is constraining process options and may require very different process designs.

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Kaspereit, M., & Schmidt-Traub, H. (2020). Process concepts. In Henner Schmit-Traub, Michael Schulte, Andreas Seidel-Morgenstern (Eds.), Preparative Chromatography: Third Edition. John Wiley & Sons, Ltd..


Kaspereit, Malte, and Henner Schmidt-Traub. "Process concepts." Preparative Chromatography: Third Edition. Ed. Henner Schmit-Traub, Michael Schulte, Andreas Seidel-Morgenstern, John Wiley & Sons, Ltd., 2020.

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