MR imaging in children with transverse myelitis and acquired demyelinating syndromes

El Naggar I, Cleaveland R, Wendel EM, Bertolini A, Schanda K, Karenfort M, Thiels C, Della Marina A, Schimmel M, Leiz S, Lechner C, Baumann M, Reindl M, Wegener-Panzer A, Rostásy K, Barišić N, Behring B, Berweck S, Blankenburg M, Blaschek A, Conrad C, Diepold K, Eckenweiler M, Eisenkölbl A, Fazeli W, Geis T, Hackenberg A, Harms K, Klein A, Koch J, Kornek B, Nosadini M, Pohl D, Pritsch M, Salandin M, Sandrieser T, Sartori S, Stoffels J, Wiegand G (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Book Volume: 67

Article Number: 104068

DOI: 10.1016/j.msard.2022.104068

Abstract

Background: Transverse myelitis (TM) occurs isolated or within other acquired demyelinating syndromes (ADS) such as neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS) or myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD). Objective: To describe and compare clinical and MRI features of children with ADS presenting with TM grouped according to antibody status and diagnosis of MS and NMOSD. Patients and methods: Children with TM, radiological involvement of the myelon, MOG and aquaporin-4 antibody status were elegible. Results: 100 children were identified and divided into MOGAD (n=33), NMOSD (n=7), double seronegative TM (n=34), and MS (n=26). MOGAD children had mainly acute disseminated encephalomyelitis + TM/ longitudinally extensive TM (LETM) (42%) or isolated LETM (30%). In MOGAD, LETM was present in more than half of all children (55%) with predominant involvement of only the grey matter (73%). Leptomeningeal enhancement was highly predictive of MOGAD (16/30; p=0.003). In MS patients spinal MRI showed single (50%) or multiple short lesions (46%) with involvement of grey and white matter (68%). Double seronegative children presented with LETM (74%) and brain lesions were less frequent compared to the other groups (30%). Conclusion: Children with ADS presenting with TM reveal important radiological differences such as LETM with predominant involvement of spinal grey matter and leptomeningeal enhancement in MOGAD.

Authors with CRIS profile

Involved external institutions

Universität Witten/Herdecke Germany (DE) Klinikum Stuttgart Germany (DE) Medizinische Universität Innsbruck Austria (AT) Heinrich-Heine-Universität Düsseldorf Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Universität Duisburg-Essen (UDE) Germany (DE) Universität Augsburg Germany (DE) Klinikum Dritter Orden Germany (DE) Klinikum der Universität München Germany (DE) Zagreb University Hospital Centre / Klinički bolnički centar Zagreb (KBC) Croatia (HR) Universitätsklinikum Freiburg Germany (DE) Kepler Universitätsklinikum (KUK) Austria (AT) Universitätsklinikum Bonn Germany (DE) Krankenhaus Barmherzige Brüder Germany (DE) Universitäts-Kinderspital Zürich Switzerland (CH) St. Elisabeth Gruppe GmbH - Katholische Kliniken Rhein-Ruhr Germany (DE) Inselspital, Universitätsspital Bern Switzerland (CH) Universitätskliniken Salzburg Austria (AT) Medizinische Universität Wien Austria (AT) Azienda Ospedale Università Padova / University Hospital of Padova Italy (IT) Children's Hospital of Eastern Ontario (CHEO) / Centre hospitalier pour enfants de l'est de l'Ontario Canada (CA) DRK-Kinderklinik Siegen Germany (DE) Gemeinschaftsklinikum Mittelrhein Germany (DE) Asklepios Klinik Altona Germany (DE)

How to cite

APA:

El Naggar, I., Cleaveland, R., Wendel, E.M., Bertolini, A., Schanda, K., Karenfort, M.,... Wiegand, G. (2022). MR imaging in children with transverse myelitis and acquired demyelinating syndromes. Multiple Sclerosis and Related Disorders, 67. https://dx.doi.org/10.1016/j.msard.2022.104068

MLA:

El Naggar, Ines, et al. "MR imaging in children with transverse myelitis and acquired demyelinating syndromes." Multiple Sclerosis and Related Disorders 67 (2022).

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