Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

Dixon-Suen SC, Lewis SJ, Martin RM, English DR, Boyle T, Giles GG, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Ahearn TU, Ambrosone CB, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Augustinsson A, Auvinen P, Beane Freeman LE, Becher H, Beckmann M, Behrens S, Bermisheva M, Blomqvist C, Bogdanova N, Bojesen SE, Bonanni B, Brenner H, Bruening T, Buys SS, Camp NJ, Campa D, Canzian F, Castelao JE, Cessna MH, Chang-Claude J, Chanock SJ, Clarke CL, Conroy DM, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Doerk T, Dwek M, Eccles DM, Eliassen AH, Engel C, Eriksson M, Evans DG, Fasching P, Fletcher O, Flyger H, Fritschi L, Gabrielson M, Gago-Dominguez M, Garcia-Closas M, Garcia-Saenz JA, Goldberg MS, Guenel P, Guendert M, Hahnen E, Haiman CA, Häberle L, Hakansson N, Hall P, Hamann U, Hart SN, Harvie M, Hillemanns P, Hollestelle A, Hooning MJ, Hoppe R, Hopper J, Howell A, Hunter DJ, Jakubowska A, Janni W, John EM, Jung A, Kaaks R, Keeman R, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kubelka-Sabit K, Kurian AW, Lacey J, Lambrechts D, Le Marchand L, Lindblom A, Loibl S, Lubinski J, Mannermaa A, Manoochehri M, Margolin S, Martinez ME, Mavroudis D, Menon U, Mulligan AM, Murphy RA, Nevanlinna H, Nevelsteen I, Newman WG, Offit K, Olshan AF, Olsson H, Orr N, Patel A, Peto J, Plaseska-Karanfilska D, Presneau N, Rack B, Radice P, Rees-Punia E, Rennert G, Rennert HS, Romero A, Saloustros E, Sandler DP, Schmidt MK, Schmutzler RK, Schwentner L, Scott C, Shah M, Shu XO, Simard J, Southey MC, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Terry MB, Tollenaar RAEM, Troester MA, Truong T, Untch M, Vachon CM, Joseph V, Wappenschmidt B, Weinberg CR, Wolk A, Yannoukakos D, Zheng W, Ziogas A, Dunning AM, Pharoah PDP, Easton DF, Milne RL, Lynch BM (2022)

Publication Type: Journal article

Publication year: 2022

Journal

DOI: 10.1136/bjsports-2021-105132

Abstract

Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.

Authors with CRIS profile

Involved external institutions

University of Bristol United Kingdom (GB) Cancer Council Victoria Australia (AU) University of South Australia Australia (AU) Cyprus Institute of Neurology and Genetics Cyprus (CY) University of Cambridge United Kingdom (GB) National Cancer Institute (NCI) United States (USA) (US) Roswell Park Cancer Institute United States (USA) (US) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Intermountain Healthcare United States (USA) (US) University of Sheffield United Kingdom (GB) Fox Chase Cancer Center United States (USA) (US) Leiden University Netherlands (NL) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Brigham and Women's Hospital (BWH) United States (USA) (US) Universität Leipzig Germany (DE) Karolinska Institute Sweden (SE) The Institute of Cancer Research (ICR) United Kingdom (GB) Copenhagen University Hospital Denmark (DK) Hospital Clínico San Carlos Spain (ES) McGill University Canada (CA) École Polytechnique - Université Paris-Saclay France (FR) Mayo Clinic United States (USA) (US) Clalit Health Services Israel (IL) General University Hospital of Larissa Greece (GR) National Institute of Environmental Health Sciences (NIEHS) United States (USA) (US) Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI / NKI-AVL) Netherlands (NL) Universität zu Köln Germany (DE) Universitätsklinikum Ulm Germany (DE) Vanderbilt University United States (USA) (US) Université Laval (UL) Canada (CA) The University of Melbourne Australia (AU) Harvard University United States (USA) (US) University of California Irvine United States (USA) (US) University of Southern California (USC) United States (USA) (US) Manchester University NHS Foundation Trust (MFT) United Kingdom (GB) Erasmus University Medical Center (MC) Netherlands (NL) Stanford University United States (USA) (US) City of Hope Medical Center United States (USA) (US) University of Hawaii (U.H.) United States (USA) (US) Södersjukhuset Sweden (SE) University of California, San Diego (UC San Diego, UCSD) United States (USA) (US) Helsingin yliopisto / University of Helsinki Finland (FI) University of North Carolina at Chapel Hill United States (USA) (US) Queen's University United Kingdom (GB) London School of Hygiene and Tropical Medicine United Kingdom (GB) University of Westminster United Kingdom (GB) American Cancer Society United States (USA) (US) Hospital Universitario Puerta de Hierro - Majadahonda Spain (ES) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS) Russian Federation (RU) University of Utah United States (USA) (US) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) University of Southampton United Kingdom (GB) HELIOS Kliniken Germany (DE) Robert-Bosch-Krankenhaus Germany (DE) European Institute of Oncology / Istituto Europeo di Oncologia (IEO) Italy (IT) Ruhr-Universität Bochum (RUB) Germany (DE) Columbia University United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) Instituto de Investigación Sanitaria Galicia Sur Spain (ES) University of Sydney (USYD) Australia (AU) University of Manchester United Kingdom (GB) Curtin University Australia (AU) Complejo Hospitalario Universitario de Santiago de Compostela Spain (ES) National Centre for Scientific Research (NCSR) "Demokritos" Greece (GR) Mount Sinai Hospital (MSH) Canada (CA) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Acibadem Sistina Hospital Republic of North Macedonia (MK) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) Belgium (BE) University of Eastern Finland Finland (FI) GBG Forschungs GmbH (German Breast Group) Germany (DE) University General Hospital of Heraklion Greece (GR) Lund University / Lunds universitet Sweden (SE) Kuopio University Hospital / Pohjois-Savon sairaanhoitopiiri Finland (FI) University College London (UCL) United Kingdom (GB) University of Toronto Canada (CA) BC Cancer Canada (CA) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Fondazione IRCCS: Istituto Nazionale dei Tumori Italy (IT)

How to cite

APA:

Dixon-Suen, S.C., Lewis, S.J., Martin, R.M., English, D.R., Boyle, T., Giles, G.G.,... Lynch, B.M. (2022). Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study. British Journal of Sports Medicine. https://doi.org/10.1136/bjsports-2021-105132

MLA:

Dixon-Suen, Suzanne C., et al. "Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study." British Journal of Sports Medicine (2022).

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