Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC

Jacobsen A, Hobbs M, Merkel S, Mittelstädt A, Czubayko F, Krautz C, Grützmann R, Brunner M, Weber G (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Journal of Clinical Medicine MDPI

Book Volume: 11

Journal Issue: 15

DOI: 10.3390/jcm11154433

Abstract

(1) Background: Delay in therapy for pancreatic ductal adenocarcinoma (PDAC) may contribute to a worse outcome. The aim of this study was to investigate the prognostic value of time from diagnosis to surgery in patients undergoing upfront surgery for primarily resectable pancreatic carcinoma. (2) Methods: This retrospective single-center study included 214 patients who underwent primary resection of PDAC from January 2000 to December 2018 at University Hospital Erlangen. Using a minimum p-value approach, patients were stratified according to time to surgery (TtS) into two groups: TtS <= 23 days and TtS > 23 days. Postoperative outcome and long-term survival were compared. (3) Results: Median TtS was 25 days. The best cut-off for TtS was determined as 23 days. There were no differences regarding postoperative outcome or overall survival (OS) and disease-free survival (DFS) (OS: 23.8 vs. 20.4 months, p = 0.210, respectively, and DFS: 15.8 vs. 13.6 months, p = 0.187). Multivariate analysis revealed age, lymph node metastasis, tumor differentiation and resection status as significant independent prognostic predictors for OS and DFS. (4) Conclusions: A delay of surgery > 23 days after first diagnosis does not affect overall or disease-free survival of patients with primary resectable PDAC. However, the psychological impact of a delay to patients waiting for surgery should not be underestimated.

Authors with CRIS profile

Anne Jacobsen Medizinische Fakultät Mirianna Hobbs Medizinische Fakultät Susanne Merkel Department of Surgery Anke Mittelstädt Department of Surgery Franziska Czubayko Department of Surgery Christian Krautz Department of Surgery Robert Grützmann Lehrstuhl für Allgemein- und Viszeralchirurgie Maximilian Brunner Lehrstuhl für Allgemein- und Viszeralchirurgie Georg Weber Department of Surgery

How to cite

APA:

Jacobsen, A., Hobbs, M., Merkel, S., Mittelstädt, A., Czubayko, F., Krautz, C.,... Weber, G. (2022). Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC. Journal of Clinical Medicine, 11(15). https://dx.doi.org/10.3390/jcm11154433

MLA:

Jacobsen, Anne, et al. "Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC." Journal of Clinical Medicine 11.15 (2022).

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