Duration of Protection After Vaccination Against Yellow Fever-Systematic Review and Meta-analysis

Kling K, Domingo C, Bogdan C, Duffy S, Harder T, Howick J, Kleijnen J, Mcdermott K, Wichmann O, Wilder-Smith A, Wolff R (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Clinical Infectious Diseases Oxford University Press (OUP): Policy A1 - Oxford Open Option C

DOI: 10.1093/cid/ciac580

Abstract

The duration of protection after a single dose of yellow fever vaccine is a matter of debate. To summarize the current knowledge, we performed a systematic literature review and meta-analysis. Studies on the duration of protection after 1 and >= 2 vaccine doses were reviewed. Data were stratified by time since vaccination. In our meta-analysis, we used random-effects models. We identified 36 studies from 20 countries, comprising more than 17 000 participants aged 6 months to 85 years. Among healthy adults and children, pooled seroprotection rates after single vaccination dose were close to 100% by 3 months and remained high in adults for 5 to 10 years. In children vaccinated before age 2 years, the seroprotection rate was 52% within 5 years after primary vaccination. For immunodeficient persons, data indicate relevant waning. The extent of waning of seroprotection after yellow fever vaccination depends on age and immune status at primary vaccination.

Authors with CRIS profile

Christian Bogdan Lehrstuhl für Mikrobiologie und Infektionsimmunologie

Involved external institutions

Robert Koch-Institut (RKI) DE Germany (DE) Kleijnen Systematic Reviews GB United Kingdom (GB) Ruprecht-Karls-Universität Heidelberg DE Germany (DE)

How to cite

APA:

Kling, K., Domingo, C., Bogdan, C., Duffy, S., Harder, T., Howick, J.,... Wolff, R. (2022). Duration of Protection After Vaccination Against Yellow Fever-Systematic Review and Meta-analysis. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciac580

MLA:

Kling, Kerstin, et al. "Duration of Protection After Vaccination Against Yellow Fever-Systematic Review and Meta-analysis." Clinical Infectious Diseases (2022).

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