MRI assessment of experimental gliomas using 17.6 T

Schwarz MA, Pham M, Helluy X, Dörfler A, Engelhorn T (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Neuroradiology Springer Verlag (Germany)

Book Volume: 55

Pages Range: 709-718

Journal Issue: 6

DOI: 10.1007/s00234-013-1149-6

Abstract

Introduction: Using ultra-high-field contrast-enhanced magnetic resonance imaging (MRI), an increase of field strength is associated with a decrease of T 1 relaxivity. Yet, the impact of this effect on signal characteristics and contrast-enhanced pathology remains unclear. Hence, we evaluated the potential of a 17.6-T MRI to assess contrast-enhancing parts of experimentally induced rat gliomas compared to 3 T. Methods: A total of eight tumor-bearing rats were used for MRI assessments either at 17.6 T (four rats) or at 3 T (four rats) at 11 days after stereotactic implantation of F98 glioma cells into the right frontal lobe. T 1-weighted sequences were used to investigate signal-to-noise-ratios, contrast-to-noise-ratios, and relative contrast enhancement up to 16 min after double-dose contrast application. In addition, tumor volumes were calculated and compared to histology. Results: The 17.6-T-derived contrast-enhancing volumes were 31.5 ± 15.4 mm3 at 4 min, 38.8 ± 12.7 mm3 at 8 min, 51.1 ± 12.6 mm3 at 12 min, and 61.5 ± 10.8 mm3 at 16 min after gadobutrol injection. Corresponding histology-derived volumes were clearly higher (138.8 ± 8.4 mm3; P < 0.01). At 3 T, contrast-enhancing volumes were 85.2 ± 11.7 mm3 at 4 min, 107.3 ± 11.0 mm3 at 8 min, 117.0 ± 10.5 mm3 at 12 min, and 129.1 ± 10.0 mm3 at 16 min after contrast agent application. Averaged histology-derived volumes (139.1 ± 13.4 mm 3) in this group were comparable to the 16-min volume (P ↠16 min = 0.38). Compared to ultra-high-field MRI, all 3-T-derived volumes were significantly higher (P < 0.02). Conclusion: Compared to 3-T-derived images and histology, tumor volumes were underestimated by approximately 50 % at 17.6 T. Hence, contrast-enhanced 17.6-T MRI provided no further benefits in tumor measurement compared to 3 T. © 2013 Springer-Verlag Berlin Heidelberg.

Authors with CRIS profile

Arnd Dörfler Department of Neuroradiology Tobias Martin Engelhorn Department of Neuroradiology

Involved external institutions

Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Schwarz, M.A., Pham, M., Helluy, X., Dörfler, A., & Engelhorn, T. (2013). MRI assessment of experimental gliomas using 17.6 T. Neuroradiology, 55(6), 709-718. https://doi.org/10.1007/s00234-013-1149-6

MLA:

Schwarz, Marc A., et al. "MRI assessment of experimental gliomas using 17.6 T." Neuroradiology 55.6 (2013): 709-718.

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