Biomedical Applications of Polyhydroxyalkanoates

Lizarraga-Valderrama LR, Panchal B, Thomas C, Boccaccini AR, Roy I (2016)

Publication Type: Authored book

Publication year: 2016

Publisher: Wiley Blackwell

ISBN: 9781119126218

DOI: 10.1002/9781119126218.ch20


Polyhydroxyalkanoates (PHAs) are a family of linear polyesters consisting of 3,4, 5 and 6-hydroxyacids, synthesized by a variety of bacterial species. PHAs are divided into two groups based on the number of carbon atoms in their monomer units; short-chain-length (scl) PHAs and medium-chain-length (mcl) PHAs. Biodegradability is an essential material property required for tissue engineering and drug delivery applications. Various methods of manufacture can be used to alter the biodegradability of PHA devices such as by blending with others polymers, increasing the porosity and increasing the exposed surface area. PHAs have also been demonstrated to be suitable for use as scaffolds in tissue engineering since they are easily degradable and favor proliferation and attachment of cells. In the field of skin tissue engineering research, various skin components, cytokines, growth factors, and transcription factors have been used experimentally. Melanocytes have been seeded on various polymer scaffolds, as well as sweat and sebaceous glands.

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Lizarraga-Valderrama, L.R., Panchal, B., Thomas, C., Boccaccini, A.R., & Roy, I. (2016). Biomedical Applications of Polyhydroxyalkanoates. Wiley Blackwell.


Lizarraga-Valderrama, L. R., et al. Biomedical Applications of Polyhydroxyalkanoates. Wiley Blackwell, 2016.

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