Blümcke I, Coras R (2012)
Publication Type: Journal article
Publication year: 2012
Book Volume: 25
Pages Range: 83-87
Journal Issue: 2
DOI: 10.1007/s10309-011-0209-3
A distinct group of brain neoplasias can be identified in 26.5% of all patients with chronic focal epilepsies undergoing epilepsy surgery. These tumors often present with an unusual histomorphological spectrum and have been designated as long-term epilepsy-associated tumors (LEAT), i.e., gangliogliomas and dysembryoplastic neuroepithelial tumors. Our series of patients were operated at a mean age of 25.4 years and had suffered from drug-resistant epilepsy for 12.6 years. Surgical tumor specimens open the possibility to address the origin and epileptogenicity of LEAT. Intriguingly, most studies failed to identify common tumor-associated genetic aberrations. In contrast, neurodevelopmentally regulated genes related to mammalian target of rapamycin (mTOR) or reelin signaling pathways are likely to play key roles and may also be involved in associated focal cortical dysplasias (FCD). Thus, research analysis of LEAT opens new avenues for understanding brain development under physiological as well as pathophysiological conditions. © Springer-Verlag 2012.
APA:
Blümcke, I., & Coras, R. (2012). Epileptogene Hirntumoren: Erkenntnisse aus neuropathologischen Untersuchungen. Zeitschrift für Epileptologie, 25(2), 83-87. https://doi.org/10.1007/s10309-011-0209-3
MLA:
Blümcke, Ingmar, and Roland Coras. "Epileptogene Hirntumoren: Erkenntnisse aus neuropathologischen Untersuchungen." Zeitschrift für Epileptologie 25.2 (2012): 83-87.
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