HINGEneering IgG for enhanced immune activation

Werner A, Nimmerjahn F (2022)

Publication Type: Journal article, Review article

Publication year: 2022


Book Volume: 7

Pages Range: eabq4797-

Journal Issue: 73

DOI: 10.1126/sciimmunol.abq4797


Two recent studies in Science Immunology by Orr et al. and Foss et al. demonstrate that the hinge region of immunoglobulin G (IgG) is a major regulator of IgG2 and IgG3 activity, respectively. Engineering of the IgG hinge may therefore be useful for optimizing the activity of IgG subclasses.

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How to cite


Werner, A., & Nimmerjahn, F. (2022). HINGEneering IgG for enhanced immune activation. Science immunology, 7(73), eabq4797-. https://doi.org/10.1126/sciimmunol.abq4797


Werner, Anja, and Falk Nimmerjahn. "HINGEneering IgG for enhanced immune activation." Science immunology 7.73 (2022): eabq4797-.

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