Tomoelastography based on multifrequency MR elastography for prostate cancer detection: Comparison with multiparametric MRI

Li M, Guo J, Hu P, Jiang H, Chen J, Hu J, Asbach P, Sack I, Li W (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Radiology Radiological Society of North America (RSNA)

Book Volume: 299

Pages Range: 362-370

Journal Issue: 2

DOI: 10.1148/RADIOL.2021201852

Abstract

Background: Multiparametric MRI is used for depiction of prostate cancer (PCa) but without consideration of the mechanical alteration of prostatic tissue by cancer. Purpose: To investigate the diagnostic performance of stiffness and fluidity quantified with tomoelastography, a multifrequency MR elastography technique, for depiction of PCa compared with multiparametric MRI with Prostate Imaging Reporting and Data System (PI-RADS) version 2.1. Materials and Methods: Prospective participants suspected to have PCa and healthy controls (HCs) underwent multiparametric MRI and tomoelastography between March 2019 and July 2020. Tomoelastography maps of shear-wave speed (c) and loss angle (φ) quantified stiffness and fluidity, respectively, for PCa and benign prostatic disease and for the peripheral and transition zones in HCs. Differences between entities and regions were analyzed by using analysis of variance or Kruskal-Wallis test. Diagnostic performance was assessed with area under the receiver operating characteristic curve (AUC) analysis. Results: There were 73 participants with PCa (mean age, 72 years ± 7 [standard deviation]), 82 with benign prostatic disease (66 years ± 7), and 53 HCs (41 years ± 14). Mean ± standard deviation of c and φwere higher in PCa (3.4 m/sec ± 0.6 and 1.3 radian ± 0.2, respectively) than in benign prostatic disease (2.6 m/sec ± 0.3 and 1.0 radian ± 0.2, respectively; P <.001) and agematched HCs (2.2 m/sec ± 0.1 and 0.8 radian ± 0.1

Involved external institutions

Central South University CN China (CN) Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Li, M., Guo, J., Hu, P., Jiang, H., Chen, J., Hu, J.,... Li, W. (2021). Tomoelastography based on multifrequency MR elastography for prostate cancer detection: Comparison with multiparametric MRI. Radiology, 299(2), 362-370. https://doi.org/10.1148/RADIOL.2021201852

MLA:

Li, Mengsi, et al. "Tomoelastography based on multifrequency MR elastography for prostate cancer detection: Comparison with multiparametric MRI." Radiology 299.2 (2021): 362-370.

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