Time-Harmonic Elastography of the Liver is Sensitive to Intrahepatic Pressure Gradient and Liver Decompression after Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation
Tzschatzsch H, Sack I, Garcia SRM, Ipek-Ugay S, Braun J, Hamm B, Althoff CE (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 43
Pages Range: 595-600
Journal Issue: 3
DOI: 10.1016/j.ultrasmedbio.2016.10.007
Abstract
We investigated the correlation between hepatic venous pressure gradient (HVPG) and liver shear wave speed (SWS) measured by multi-frequency time-harmonic ultrasound elastography (THE) before and after transjugular intrahepatic portosystemic shunt (TIPS) implantation. Ten patients with ascites, cirrhotic liver disease and portal hypertension were prospectively examined with invasive HVPG measurement and THE before and after TIPS implantation. HVPG and SWS decreased after TIPS placement from 20.4 ± 2.2 mmHg to 9.8 ± 4.1 mmHg (mean ± standard deviation) and from 3.87 ± 0.54 m/s to 3.27 ± 0.44 m/s. Mean reduction HVPG was −10.6 ± 3.7 mmHg, p < 0.001; mean reduction SWS was −0.60 ± 0.29 m/s, p < 0.001. A linear correlation was observed between HVPG and SWS (R = 0.59, p = 0.0061). THE-measured SWS is a first potential direct ultrasound marker for liver decompression following TIPS in ascites-associated cirrhotic liver disease and therefore might be suitable to non-invasively detect portal hypertension.
Involved external institutions
Germany (DE)How to cite
APA:
Tzschatzsch, H., Sack, I., Garcia, S.R.M., Ipek-Ugay, S., Braun, J., Hamm, B., & Althoff, C.E. (2017). Time-Harmonic Elastography of the Liver is Sensitive to Intrahepatic Pressure Gradient and Liver Decompression after Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation. Ultrasound in Medicine and Biology, 43(3), 595-600. https://doi.org/10.1016/j.ultrasmedbio.2016.10.007
MLA:
Tzschatzsch, Heiko, et al. "Time-Harmonic Elastography of the Liver is Sensitive to Intrahepatic Pressure Gradient and Liver Decompression after Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation." Ultrasound in Medicine and Biology 43.3 (2017): 595-600.
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