Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis

Li Y, Cao S, Gaculenko A, Zhan Y, Bozec A, Chen X (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Frontiers in Endocrinology Frontiers Media

Book Volume: 13

Article Number: 902033

DOI: 10.3389/fendo.2022.902033

Abstract

Bone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by actively secreting fatty acids, cytokines, and adipokines. The volume of BMAs increases along with age, osteoporosis and/or obesity. With the rapid development of multi-omic analysis and the advance in in vivo imaging technology, further distinct characteristics and functions of BMAs have been revealed. There is accumulating evidence that BMAs are metabolically, biologically and functionally unique from white, brown, beige and pink adipocytes. Bone metastatic disease is an uncurable complication in cancer patients, where primary cancer cells spread from their original site into the bone marrow. Recent publications have highlighted those BMAs could also serve as a rich lipid source of fatty acids that can be utilized by the cancer cells during bone metastasis, particularly for breast, prostate, lung, ovarian and pancreatic cancer as well as melanoma. In this review, we summarize the novel progressions in BMAs metabolism, especially with multi-omic analysis and in vivo imaging technology. We also update the metabolic role of BMAs in bone metastasis, and their potential new avenues for diagnosis and therapies against metastatic cancers.

Authors with CRIS profile

Anastasia Gaculenko Department of Medicine 3 – Rheumatology and Immunology Aline Bozec Professur für Experimentelle Immuntherapie

Involved external institutions

Shanghai Jiao Tong University / 上海交通大学 CN China (CN) Shanghai Novamab Biopharmaceuticals Co., Ltd / 上海洛启生物医药技术有限公司 CN China (CN)

How to cite

APA:

Li, Y., Cao, S., Gaculenko, A., Zhan, Y., Bozec, A., & Chen, X. (2022). Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis. Frontiers in Endocrinology, 13. https://dx.doi.org/10.3389/fendo.2022.902033

MLA:

Li, Yixuan, et al. "Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis." Frontiers in Endocrinology 13 (2022).

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