Biodegradable Polylactide Supraparticle Powders with Functional Additives for Biomedical Additive Manufacturing

Canziani H, Hanschmann B, Tischer F, Sommereyns A, Distler T, Schramm J, Hesse N, Schmidt J, Grünewald A, Detsch R, Boccaccini AR, Maskos M, Schmidt M, Vogel N (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Advanced Functional Materials Wiley-VCH Verlag

Pages Range: 2205730

DOI: 10.1002/adfm.202205730

Abstract

Additive manufacturing, in particular powder bed-based fabrication processes hold promise to revolutionize biomedical engineering for the ability to provide customized, functional implants, for example as bone replacement materials. However, providing functional powder particles that unify material requirements for biodegradable and bioactive biomaterials and process requirements to enable successful powder bed fusion remains an unmet challenge. Here, a supraparticle-based approach to create biodegradable poly(lactic acid) and composite powders for the additive manufacturing of bone replacement materials is introduced. Colloidal binary Ca-SiO2 glasses and hydroxyapatite are incorporated as bioactive functional additives to support the formation of bone-like calcium phosphate. The supraparticle powders are prepared by a scalable spray-drying process, which offers control of particle size, shape, and composition. All process-relevant powder characteristics are analyzed as a function of composition and structure, including flowability, thermal, and melt rheological properties. The optimized supraparticle powders are successfully used in the process of laser powder bed fusion of polymers to prepare macroscopic specimens via additive manufacturing. It is demonstrated that the material combination of the composites provides relevant functional properties, including biodegradation and bioactivity. The process provides a flexible and adjustable toolbox for the design of functional powders toward biomedical additive manufacturing.

Authors with CRIS profile

Herbert Canziani Professur für Partikelsynthese Benedikt Hanschmann Professur für Partikeltechnik Florentin Riedel Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Alexander Sommereyns Lehrstuhl für Photonische Technologien Thomas Distler Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Nicolas Hesse Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Jochen Schmidt Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Alina Grünewald Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Michael Schmidt Lehrstuhl für Photonische Technologien Nicolas Vogel Professur für Partikelsynthese

Additional Organisation(s)

Erlangen Graduate School in Advanced Optical Technologies

Involved external institutions

Fachhochschule Mainz DE Germany (DE) Fraunhofer-Institut für Mikrotechnik und Mikrosysteme IMM / Fraunhofer Institute for Microengineering and Microsystems DE Germany (DE)

How to cite

APA:

Canziani, H., Hanschmann, B., Tischer, F., Sommereyns, A., Distler, T., Schramm, J.,... Vogel, N. (2022). Biodegradable Polylactide Supraparticle Powders with Functional Additives for Biomedical Additive Manufacturing. Advanced Functional Materials, 2205730. https://doi.org/10.1002/adfm.202205730

MLA:

Canziani, Herbert, et al. "Biodegradable Polylactide Supraparticle Powders with Functional Additives for Biomedical Additive Manufacturing." Advanced Functional Materials (2022): 2205730.

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