Vedolizumab blocks alpha 4 beta 7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis

Besendorf L, Müller T, Geppert CI, Schneider I, Mühl L, Atreya I, Vitali F, Atreya R, Neurath M, Zundler S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Therapeutic Advances in Gastroenterology SAGE Publications

Book Volume: 15

DOI: 10.1177/17562848221098899

Abstract

Background: In Crohn's disease and ulcerative colitis, the anti-alpha 4 beta 7 integrin antibody vedolizumab has demonstrated efficacy in phase III trials and has been successfully used under real-world conditions. Occasionally, it has also been used in other forms of inflammatory bowel disease (IBD) such as microscopic colitis (MC). However, the mechanisms of vedolizumab in MC have not been studied to date. Therefore, we aimed to investigate the expression and functional role of gut-homing integrins and in particular alpha 4 beta 7 integrin in a cohort study in MC.

Authors with CRIS profile

Laura Besendorf Medizinische Fakultät Tanja Müller Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Carol-Immanuel Geppert Institute of Pathology Laura Mühl Medizinische Fakultät Imke Atreya Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Francesco Vitali Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur) Markus Neurath Lehrstuhl für Innere Medizin I Sebastian Zundler Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

How to cite

APA:

Besendorf, L., Müller, T., Geppert, C.-I., Schneider, I., Mühl, L., Atreya, I.,... Zundler, S. (2022). Vedolizumab blocks alpha 4 beta 7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis. Therapeutic Advances in Gastroenterology, 15. https://doi.org/10.1177/17562848221098899

MLA:

Besendorf, Laura, et al. "Vedolizumab blocks alpha 4 beta 7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis." Therapeutic Advances in Gastroenterology 15 (2022).

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