Sinonasal mixed transitional epithelial-seromucinous papillary glandular neoplasms with BRAF p.V600E mutations — sinonasal analogues to the sialadenoma papilliferum family tumors

Patel S, Snyderman CH, Mueller SK, Agaimy A, Seethala RR (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Virchows Archiv Springer Verlag (Germany)

Abstract

Sinonasal non-intestinal type adenocarcinoma (non-ITAC) is a heterogeneous category that may benefit from improved taxonomy. With the recognition that most non-ITAC are phenotypically seromucinous, stratification may be improved by applying salivary type morphologic criteria and molecular findings. We report two cases of papillary seromucinous adenocarcinoma with sinonasal papilloma-like surface components that show histologic and molecular features analogous to the salivary sialadenoma papilliferum family of tumors. Case 1 concerns a 50-year-old female who presented with a left anterior nasoethmoid polyp, while case 2 is that of a 74 year old female with nasal polyposis. Histologically, both cases demonstrated a surface transitional sinonasal papilloma-like component (more prominent in case 2) with a deeper bilayered glandular component showing papillary and tufted micropapillary growth of monomorphic columnar to cuboidal cells with eosinophilic cytoplasm. Case 1 also showed a deep cribriform/microcystic component. Immunostains showed a delimiting p63/p40 positive basal layer around the SOX-10 positive glandular elements, while the transitional sinonasal papilloma-like components were diffusely p63/p40 positive. Like sialadenoma papilliferum and related tumors, both cases demonstrated BRAF p.V600E mutations in both components and no other alterations. The patients remain disease free at 9 and 19 months respectively. Our cases illustrate a novel sinonasal lesion and suggest that improved morphologic and molecular categorization may refine and reduce the category of non-ITAC.

Authors with CRIS profile

Sarina Müller-Hübner Department of Otorhinolaryngology – Head and Neck Surgery Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

University of Pittsburgh

United States (USA) (US)

How to cite

APA:

Patel, S., Snyderman, C.H., Mueller, S.K., Agaimy, A., & Seethala, R.R. (2022). Sinonasal mixed transitional epithelial-seromucinous papillary glandular neoplasms with BRAF p.V600E mutations — sinonasal analogues to the sialadenoma papilliferum family tumors. Virchows Archiv. https://doi.org/10.1007/s00428-022-03359-8

MLA:

Patel, Simmi, et al. "Sinonasal mixed transitional epithelial-seromucinous papillary glandular neoplasms with BRAF p.V600E mutations — sinonasal analogues to the sialadenoma papilliferum family tumors." Virchows Archiv (2022).

BibTeX: Download