Distribution of magnetic nanoparticles after magnetic drug targeting in an ex vivo bovine artery model

Lyer S, Tietze R, Jurgons R, Richter H, Wiekhorst F, Schwarz K, Trahms L, Alexiou C (2009)

Publication Type: Conference contribution

Publication year: 2009

Journal

4th European Conference of the International Federation for Medical and Biological Engineering Springer Science Business Media

Publisher: Springer Verlag

Book Volume: 25

Pages Range: 484-487

Conference Proceedings Title: IFMBE Proceedings

ISBN: 9783642038846

DOI: 10.1007/978-3-642-03885-3_134

Abstract

The aim of Magnetic Drug Targeting (MDT) in cancer therapy is to concentrate chemotherapeutics to a tumor region while simultaneously the over all dose is reduced. This can be achieved by coated superparamagnetic nanoparticles bound to a chemotherapeutic agent. These particles are applied intraarterially close to the tumor region and focused to the tumor by a strong external magnetic field. The interaction of the particles with the field should make them accumulate in the region of the steepest field gradient. Here, we suggest an artery model by which the magnetic targeting mechanism can be studied in detail. In particular, we focus on the quantification of the accumulation profile along the artery by SQUID-based magnetorelaxometry. © 2009 Springer-Verlag.

Authors with CRIS profile

Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Rainer Tietze Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Physikalisch-Technische Bundesanstalt (PTB) DE Germany (DE)

How to cite

APA:

Lyer, S., Tietze, R., Jurgons, R., Richter, H., Wiekhorst, F., Schwarz, K.,... Alexiou, C. (2009). Distribution of magnetic nanoparticles after magnetic drug targeting in an ex vivo bovine artery model. In IFMBE Proceedings (pp. 484-487). Springer Verlag.

MLA:

Lyer, Stefan, et al. "Distribution of magnetic nanoparticles after magnetic drug targeting in an ex vivo bovine artery model." Proceedings of the World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering Springer Verlag, 2009. 484-487.

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