SRμCT and MRX analysis of ferrofluid accumulation in bovine arteries: A step further in the understanding of Magnetic Drug Targeting
Rahn H, Lyer S, Tietze R, Richter H, Alexiou C, Eberbeck D, Wiekhorst F, Trahms L, Beckmann F, Odenbach S (2010)
Publication Type: Conference contribution
Publication year: 2010
Journal
Publisher: Elsevier B.V.
Book Volume: 9
Pages Range: 258-261
Conference Proceedings Title: Physics Procedia
DOI: 10.1016/j.phpro.2010.11.057
Abstract
Cancer is one of the most deadly and widespread diseases nowadays. Local cancer treatments are gaining strong importance. Magnetic Drug Targeting and magnetic heating treatment are minimal invasive cancer treatments that make use of magnetic nanoparticles as drug carriers in the first case and to induce heat transfer in the second case. For MDT the application of drugs, bound to magnetic nanoparticles, is realized via the tumor supplying vessels while a strong magnetic field gradient influences the flow and directs the nanoparticles to the respective region. In order to understand the mechanisms behind this magnetically controlled drug delivery, an ex-vivo artery model has been established. To study the amount and the distribution of magnetic nanoparticles within the arteries, microcomputed tomography and magnetorelaxometry have been used as analytical techniques. MRX provides very sensitively the amount of magnetic nanoparticles, while microcomputed tomography based on a synchrotron beam line enables 3-dimensional non-destructive examination of the distribution of the magnetic nanoparticles at a spatial resolution of a few micrometers. In this paper we present first results concerning the quantitative study of accumulation of nanoparticles within bovine arteries streamed with magnetic nanoparticles. © 2010 Published by Elsevier Ltd.
Authors with CRIS profile
Stefan Lyer
Medizinische Fakultät
Rainer Tietze
Medizinische Fakultät
Christoph Alexiou
Medizinische Fakultät
Involved external institutions
Technische Universität Dresden
Germany (DE)
Physikalisch-Technische Bundesanstalt (PTB)
Germany (DE)
Helmholtz-Zentrum Hereon
Germany (DE)
Germany (DE)
Physikalisch-Technische Bundesanstalt (PTB)
Germany (DE)
Helmholtz-Zentrum Hereon
Germany (DE)
How to cite
APA:
Rahn, H., Lyer, S., Tietze, R., Richter, H., Alexiou, C., Eberbeck, D.,... Odenbach, S. (2010). SRμCT and MRX analysis of ferrofluid accumulation in bovine arteries: A step further in the understanding of Magnetic Drug Targeting. In Physics Procedia (pp. 258-261). Elsevier B.V..
MLA:
Rahn, H., et al. "SRμCT and MRX analysis of ferrofluid accumulation in bovine arteries: A step further in the understanding of Magnetic Drug Targeting." Proceedings of the 12th International Conference on Magnetic Fluids Elsevier B.V., 2010. 258-261.
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