Zinc improves antibacterial, anti-inflammatory and cell motility activity of chitosan for wound healing applications

Mutlu N, Liverani L, Kurtuldu F, Galusek D, Boccaccini AR (2022)

Publication Type: Journal article

Publication year: 2022

Journal

International Journal of Biological Macromolecules Elsevier

Book Volume: 213

Pages Range: 845-857

DOI: 10.1016/j.ijbiomac.2022.05.199

Abstract

We report the successful preparation and characterization of chitosan-Zn complex (ChiZn) in the form of films, intended to enhance the biological performance of chitosan by the presence of Zn as antibacterial agent and biologically active ion. The influence of Zn chelation on morphology and structure of chitosan was assessed by scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and infrared spectroscopy. The biodegradability study of ChiZn showed a sustained release of Zn up to 2 mg/mL. No toxic response was observed toward stromal cell line ST-2 in indirect contact with the ChiZn films. The dissolution product of ChiZn showed improved wound closure (88% closure) compared to the positive control group (70% closure). Moreover, ChiZn exhibited antibacterial activity against S. aureus together with a slight increase (~30%) in the secretion of VEGF and moderate decrease in nitric oxide evolution. Our findings indicate that ChiZn could be used as a safe and effective wound healing agent.

Authors with CRIS profile

Nurshen Mutlu Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Fatih Kurtuldu Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Slovak Academy of Sciences (SAS) / Slovenská akadémia vied (SAV) SK Slovakia (SK)

How to cite

APA:

Mutlu, N., Liverani, L., Kurtuldu, F., Galusek, D., & Boccaccini, A.R. (2022). Zinc improves antibacterial, anti-inflammatory and cell motility activity of chitosan for wound healing applications. International Journal of Biological Macromolecules, 213, 845-857. https://doi.org/10.1016/j.ijbiomac.2022.05.199

MLA:

Mutlu, Nurshen, et al. "Zinc improves antibacterial, anti-inflammatory and cell motility activity of chitosan for wound healing applications." International Journal of Biological Macromolecules 213 (2022): 845-857.

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