Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma

Mikuteit M, Steffens S, Zschäbitz S, Autenrieth M, Weichert W, Hartmann A, Erlmeier F (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Oncology Karger

Book Volume: 100

Pages Range: 331-336

Journal Issue: 6

DOI: 10.1159/000522592

Abstract

BACKGROUND: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. AIM: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. MATERIALS AND METHODS: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. RESULTS: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2- compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). CONCLUSION: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Franziska Erlmeier Institute of Pathology

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Klinikum rechts der Isar DE Germany (DE) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Mikuteit, M., Steffens, S., Zschäbitz, S., Autenrieth, M., Weichert, W., Hartmann, A., & Erlmeier, F. (2022). Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma. Oncology, 100(6), 331-336. https://doi.org/10.1159/000522592

MLA:

Mikuteit, Marie, et al. "Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma." Oncology 100.6 (2022): 331-336.

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