IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.
Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, Mckenzie AN, Walsh PT, Fallon PG (2017)
Publication Status: Published
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 199
Pages Range: 707-717
Journal Issue: 2
Abstract
mice was dependent on TSLP, but not the other alarmins IL-25 and IL-33. The associated skin inflammation was mediated by IL-5-expressing pathogenic effector Th2 cells and was independent of TCRγδ T cells and IL-22. An absence of IL-17RA in nonhematopoietic cells, but not in the hematopoietic cells, was required for the development of spontaneous skin inflammation. Skin microbiome dysbiosis developed in the absence of IL-17RA, with antibiotic intervention resulting in significant amelioration of skin inflammation and reductions in skin-infiltrating pathogenic effector Th2 cells and TSLP. This study describes a previously unappreciated protective role for IL-17RA signaling in regulation of the skin barrier and maintenance of skin immune homeostasis.
Authors with CRIS profile
Involved external institutions
University of Oxford
United Kingdom (GB)
Trinity College Dublin
Ireland (IE)
Queen's University
United Kingdom (GB)
Medical Research Council
United Kingdom (GB)
United Kingdom (GB)
Trinity College Dublin
Ireland (IE)
Queen's University
United Kingdom (GB)
Medical Research Council
United Kingdom (GB)
How to cite
APA:
Floudas, A., Saunders, S.P., Moran, T., Schwartz, C., Hams, E., Fitzgerald, D.C.,... Fallon, P.G. (2017). IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation. Journal of Immunology, 199(2), 707-717. https://doi.org/10.4049/jimmunol.1602185
MLA:
Floudas, Achilleas, et al. "IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation." Journal of Immunology 199.2 (2017): 707-717.
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