Artificial intelligence in cancer target identification and drug discovery

You Y, Lai X, Pan Y, Zheng H, Vera J, Liu S, Deng S, Zhang L (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Signal Transduction and Targeted Therapy Springer Nature

Book Volume: 7

Journal Issue: 1

DOI: 10.1038/s41392-022-00994-0

Abstract

Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as cancer. Here, we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover drugs. First, we describe the scope of artificial intelligence biology analysis for novel anticancer target investigations. Second, we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence algorithms. Finally, we showcase the applications of artificial intelligence approaches in cancer target identification and drug discovery. Taken together, the artificial intelligence models have provided us with a quantitative framework to study the relationship between network characteristics and cancer, thereby leading to the identification of potential anticancer targets and the discovery of novel drug candidates.

Authors with CRIS profile

Xin Lai Department of Dermatology Julio Vera González Professur für Tumorimmunologie (Schwerpunkt Systembiologie)

Involved external institutions

Sichuan University (SCU) / 四川大学 CN China (CN) Chinese Academy of Sciences (CAS) / 中国科学院 CN China (CN) University of Ulster GB United Kingdom (GB)

How to cite

APA:

You, Y., Lai, X., Pan, Y., Zheng, H., Vera, J., Liu, S.,... Zhang, L. (2022). Artificial intelligence in cancer target identification and drug discovery. Signal Transduction and Targeted Therapy, 7(1). https://dx.doi.org/10.1038/s41392-022-00994-0

MLA:

You, Yujie, et al. "Artificial intelligence in cancer target identification and drug discovery." Signal Transduction and Targeted Therapy 7.1 (2022).

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