Tumor Infiltration with CD20+CD73+ B Cells Correlates with Better Outcome in Colorectal Cancer

Hansen F, Wu Z, David P, Mittelstädt A, Jacobsen A, Podolska M, Ubieta Hernández K, Brunner M, Kouhestani D, Swierzy I, Roßdeutsch L, Klösch B, Kutschick I, Merkel S, Denz A, Weber K, Geppert CI, Grützmann R, Benard A, Weber G (2022)


Publication Type: Journal article

Publication year: 2022

Journal

Book Volume: 23

Article Number: 5163

Journal Issue: 9

DOI: 10.3390/ijms23095163

Abstract

Immunotherapy has become increasingly important in the treatment of colorectal cancer (CRC). Currently, CD73, also known as ecto-5-nucleotidase (NT5E), has gained considerable interest as a potential therapeutic target. CD73 is one of the key enzymes catalyzing the conversion of extracellular ATP into adenosine, which in turn exerts potent immune suppressive effects. However, the role of CD73 expression on various cell types within the CRC tumor microenvironment remains unresolved. The expression of CD73 on various cell types has been described recently, but the role of CD73 on B-cells in CRC remains unclear. Therefore, we analyzed CD73 on B-cells, especially on tumor-infiltrating B-cells, in paired tumor and adjacent normal tissue samples from 62 eligible CRC patients. The highest expression of CD73 on tumor-infiltrating B-cells was identified on classswitched memory B-cells, followed by naive B-cells, whereas no CD73 expression was observed on plasmablasts. Clinicopathological correlation analysis revealed that higher CD73+ B-cells infiltration in the CRC tumors was associated with better overall survival. Moreover, metastasized patients showed a significantly decreased number of tumor-infiltrating CD73+ B-cells. Finally, neoadjuvant therapy correlated with reduced CD73+ B-cell numbers and CD73 expression on B-cells in the CRC tumors. As promising new immune therapies are being developed, the role of CD73+ B-cells and their subsets in the development of colorectal cancer should be further explored to find new therapeutic options.

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How to cite

APA:

Hansen, F., Wu, Z., David, P., Mittelstädt, A., Jacobsen, A., Podolska, M.,... Weber, G. (2022). Tumor Infiltration with CD20+CD73+ B Cells Correlates with Better Outcome in Colorectal Cancer. International Journal of Molecular Sciences, 23(9). https://doi.org/10.3390/ijms23095163

MLA:

Hansen, Frederik, et al. "Tumor Infiltration with CD20+CD73+ B Cells Correlates with Better Outcome in Colorectal Cancer." International Journal of Molecular Sciences 23.9 (2022).

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