Oxidoreductase mimicking activity of Ru(edta) complexes in conversion of NAD coenzymes

Chrzanowska M, Katafias A, van Eldik R, Chatterjee D (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Polyhedron Elsevier

Book Volume: 221

Article Number: 115872

DOI: 10.1016/j.poly.2022.115872

Abstract

The realization of the reversible inter-conversion between NAD+ and NADH (Scheme 1) is a long-term challenge in biological and energy-related chemistry. Potential of Ru(edta) complexes mimicking oxidoreductase enzymes in the redox conversion of NAD coenzymes has been explored in the present work. The oxidation of NADH to NAD+ by [RuIII(edta)(pz)]- (edta4- = ethylenediaminetetraacetate; pz = pyrazine) has been studied spectrophotometrically and kinetically in aqueous solution at pH 7.0 (mes buffer) as a function of [NADH] and temperature. A working mechanism for the [RuIII(edta)(pz)]- complex mediated redox conversion of NAD coenzymes has been proposed. A mechanism in agreement with the kinetic data and activation parameters is presented.

Authors with CRIS profile

Rudi van Eldik Naturwissenschaftliche Fakultät

Involved external institutions

Nicolaus Copernicus University (NCU) / Uniwersytet Mikołaja Kopernika w Toruniu (UMK) PL Poland (PL)

How to cite

APA:

Chrzanowska, M., Katafias, A., van Eldik, R., & Chatterjee, D. (2022). Oxidoreductase mimicking activity of Ru(edta) complexes in conversion of NAD coenzymes. Polyhedron, 221. https://doi.org/10.1016/j.poly.2022.115872

MLA:

Chrzanowska, Marta, et al. "Oxidoreductase mimicking activity of Ru(edta) complexes in conversion of NAD coenzymes." Polyhedron 221 (2022).

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